Protein profile

PA0262

hypothetical protein

Genome: NC_002516.2

Gene: vgrG2b PA0262 Structure source: Experimental + AlphaFold UniProt Q9I6M7
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Amino acids 1019
Annotations 6
Features 22
PDB binders 0
Druggability 0.891

Overview

Basic information about this protein and its source genome.

Accession
PA0262
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
vgrG2b PA0262
Status
annotated
Amino acids
1019
Structure source
Experimental + AlphaFold
EC
3.4.24.-
GO
GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0033104 A complex of proteins that permits the transfer of proteins into the extracellular milieu or directly into host cells via the type VI secretion system. Proteins secreted by this complex do not require an N-terminal signal sequence. GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872 Binding to a metal ion. GO:0033103 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.891
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

5
  • GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
  • GO:0033104 A complex of proteins that permits the transfer of proteins into the extracellular milieu or directly into host cells via the type VI secretion system. Proteins secreted by this complex do not require an N-terminal signal sequence.
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
  • GO:0046872 Binding to a metal ion.
  • GO:0033103 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
475 581 Pfam PF13296 Putative type VI secretion system Rhs element Vgr
475 581 InterPro IPR028244 Putative type VI secretion system, Rhs element associated Vgr domain
386 453 Pfam PF04717 Type VI secretion system/phage-baseplate injector OB domain
386 453 InterPro IPR006531 Gp5/Type VI secretion system Vgr protein, OB-fold domain
615 758 Pfam PF10106 Uncharacterized protein conserved in bacteria (DUF2345)
615 758 InterPro IPR018769 Type VI secretion system spike protein VgrG2, domain of unknown function DUF2345
96 187 Gene3D G3DSA:3.55.50.10 -
21 328 Gene3D G3DSA:2.30.110.50 -
442 493 SUPERFAMILY SSF69349 Phage fibre proteins
9 493 NCBIfam TIGR03361 type VI secretion system tip protein TssI/VgrG N-terminal domain
9 493 InterPro IPR017847 Type VI secretion system, RhsGE-associated Vgr family subset
221 284 Gene3D G3DSA:4.10.220.110 -
3 724 PANTHER PTHR32305 -
9 182 SUPERFAMILY SSF69279 Phage tail proteins
197 365 SUPERFAMILY SSF69279 Phage tail proteins
358 456 Gene3D G3DSA:2.40.50.230 -
358 456 InterPro IPR037026 Vgr protein, OB-fold domain superfamily
19 502 NCBIfam TIGR01646 type VI secretion system tip protein VgrG
19 502 InterPro IPR006533 Type VI secretion system, RhsGE-associated Vgr protein
27 327 Pfam PF05954 Phage tail baseplate hub (GPD)
364 451 SUPERFAMILY SSF69255 gp5 N-terminal domain-like
584 621 MobiDBLite mobidb-lite consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 6H56
X-ray 3.20 Å A,B
24.5% 770-1019
PDBe RCSB PDBj File
Viewing
AlphaFold PA0262
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.891
2 0.822

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 11.44 0.611
2 4.96 0.224
3 1.3 0.014