Protein profile

PA0263

secreted protein Hcp

Genome: NC_002516.2

Gene: PA5267 PA0263; hcpB hcpA hcpC PA1512; Structure source: Experimental + AlphaFold UniProt Q9HI36
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Amino acids 172
Annotations 0
Features 9
PDB binders 0
Druggability 0.217

Overview

Basic information about this protein and its source genome.

Accession
PA0263
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5267 PA0263; hcpB hcpA hcpC PA1512;
Status
annotated
Amino acids
172
Structure source
Experimental + AlphaFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Extracellular

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.217
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
2 172 Gene3D G3DSA:2.30.110.20 -
2 172 InterPro IPR036624 Hcp1-like superfamily
1 163 PANTHER PTHR34319 MAJOR EXPORTED PROTEIN
1 168 NCBIfam TIGR03344 type VI secretion system tube protein TssD/Hcp
1 168 InterPro IPR008514 Type VI secretion system effector Hcp
6 155 Pfam PF05638 Type VI secretion system effector, Hcp
6 155 InterPro IPR008514 Type VI secretion system effector Hcp
2 171 SUPERFAMILY SSF141452 Hcp1-like
2 171 InterPro IPR036624 Hcp1-like superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 3HE1
X-ray 2.10 Å A,B,C,D,E,F
100.0% 1-172
PDBe RCSB PDBj File
Viewing
AlphaFold PA0263
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.217

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.11 0.048