Protein profile

PA0269

hypothetical protein

Genome: NC_002516.2

Gene: PA0269 Structure source: Experimental + AlphaFold UniProt Q9I6M1
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Amino acids 145
Annotations 1
Features 9
PDB binders 0
Druggability 0.737

Overview

Basic information about this protein and its source genome.

Accession
PA0269
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0269
Status
annotated
Amino acids
145
Structure source
Experimental + AlphaFold
GO
GO:0051920 Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.737
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MTTRLEWAKASPDAYAAMLGLEKALAKAGLERPLIELVYLRTSQINGCAYCVNMHANDARKAGETEQRLQALCVWQETPYFTPRERAALAWTEQLARLSQGALPHGLLDELREHFDDKEIAELTLAVSAINAWNRFGVGMGMQPE

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0051920 Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
6 145 PANTHER PTHR34846 4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)
6 145 SUPERFAMILY SSF69118 AhpD-like
6 145 InterPro IPR029032 AhpD-like
1 145 Gene3D G3DSA:1.20.1290.10 -
1 145 InterPro IPR029032 AhpD-like
29 76 NCBIfam TIGR00778 alkylhydroperoxidase AhpD family core domain
29 76 InterPro IPR004675 Alkylhydroperoxidase AhpD core
12 93 Pfam PF02627 Carboxymuconolactone decarboxylase family
12 93 InterPro IPR003779 Carboxymuconolactone decarboxylase-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

2 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 2O4D
X-ray 1.85 Å A
100.0% 1-145
PDBe RCSB PDBj File
Viewing
PDB 2IJC
X-ray 2.05 Å A,B,C,D,E,F,G,H,I
100.0% 1-145
PDBe RCSB PDBj File
Loaded
AlphaFold PA0269
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.737

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 14.19 0.714