Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA0279
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA0279
Status: annotated
Amino acids: 232
Structure source: AlphaFold

GO

GO:0097063 Binding to and responding, e.g. by conformational change, to changes in the cellular level of cadmium (Cd++). GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0032791 Binding to lead (Pb) ions. GO:0010468 Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). GO:0046686 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.931

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

8 GO

Gene Ontology (GO)

8

GO:0097063 Binding to and responding, e.g. by conformational change, to changes in the cellular level of cadmium (Cd++).
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
GO:0032791 Binding to lead (Pb) ions.
GO:0010468 Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
GO:0046686 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
GO:0010288 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus.
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records

Show feature table

Start	End	DB	Term	Name
1	94	ProSiteProfiles	PS50987	ArsR-type HTH domain profile.
1	94	InterPro	IPR001845	HTH ArsR-type DNA-binding domain
1	6	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
6	94	Gene3D	G3DSA:1.10.10.10	-
6	94	InterPro	IPR036388	Winged helix-like DNA-binding domain superfamily
9	88	SMART	SM00418	arsrmega2
9	88	InterPro	IPR001845	HTH ArsR-type DNA-binding domain
16	20	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
9	86	SUPERFAMILY	SSF46785	Winged helix DNA-binding domain
9	86	InterPro	IPR036390	Winged helix DNA-binding domain superfamily
21	232	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1	227	PANTHER	PTHR39168	TRANSCRIPTIONAL REGULATOR-RELATED
11	86	CDD	cd00090	HTH_ARSR
11	86	InterPro	IPR011991	ArsR-like helix-turn-helix domain
7	15	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
1	20	Phobius	SIGNAL_PEPTIDE	Signal peptide region
11	26	PRINTS	PR00778	Bacterial regulatory protein ArsR family signature
11	26	InterPro	IPR001845	HTH ArsR-type DNA-binding domain
44	59	PRINTS	PR00778	Bacterial regulatory protein ArsR family signature
44	59	InterPro	IPR001845	HTH ArsR-type DNA-binding domain
59	74	PRINTS	PR00778	Bacterial regulatory protein ArsR family signature
59	74	InterPro	IPR001845	HTH ArsR-type DNA-binding domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0279	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.931
6				0.388

PA0279