Protein profile

PA0291

anaerobically-induced outer membrane porin OprE

Genome: NC_002516.2

Gene: PA0291 oprE Structure source: Experimental + AlphaFold UniProt G3XDA5
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Amino acids 460
Annotations 3
Features 15
PDB binders 3
Druggability 0.542

Overview

Basic information about this protein and its source genome.

Accession
PA0291
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0291 oprE
Status
annotated
Amino acids
460
Structure source
Experimental + AlphaFold
GO
GO:0019867 The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. GO:0015288 Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
OuterMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.542
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0019867 The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.
  • GO:0015288 Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
11 33 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 10 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
35 460 Gene3D G3DSA:2.40.160.10 Porin
35 460 InterPro IPR023614 Porin domain superfamily
1 29 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 29 SignalP_EUK SignalP-noTM SignalP-noTM
35 460 FunFam G3DSA:2.40.160.10:FF:000025 Outer membrane porin OprE
1 29 Phobius SIGNAL_PEPTIDE Signal peptide region
25 29 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
30 458 Pfam PF03573 outer membrane porin, OprD family
30 458 InterPro IPR005318 Outer membrane porin, bacterial
30 460 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 460 PANTHER PTHR34596 CHITOPORIN
1 460 InterPro IPR005318 Outer membrane porin, bacterial
11 24 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 4FRX
X-ray 1.90 Å A,B
93.7% 30-460
PDBe RCSB PDBj File
Viewing
AlphaFold PA0291
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
11 0.542
1 0.49
8 0.412

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 11.25 0.602
2 3.38 0.121
3 3.33 0.118
4 2.61 0.075
5 1.92 0.039

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

53 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

Show only:
Ligand Source crystal MW · LogP · TPSA Lipinski PAINS SMILES
C8E
4FRX 1.90 Å Open crystal
306.4 Da LogP 2.41 TPSA 57.2 ✓ Ro5 ✓ Clean CCCCCCCCOCCOCCOCCOCCO

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.