Protein profile

PA0297

glutamine amidotransferase

Genome: NC_002516.2

Gene: PA0297 spuA Structure source: Experimental + AlphaFold UniProt Q9I6J4
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Amino acids 250
Annotations 7
Features 11
PDB binders 0
Druggability 0.472

Overview

Basic information about this protein and its source genome.

Accession
PA0297
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0297 spuA
Status
annotated
Amino acids
250
Structure source
Experimental + AlphaFold
EC
3.5.1.94
GO
GO:0033969 Catalysis of the reaction: 4-(L-gamma-glutamylamino)butanoate + H2O = 4-aminobutanoate + L-glutamate. GO:0046872 Binding to a metal ion. GO:0006598 The chemical reactions and pathways resulting in the breakdown of polyamines, any organic compound containing two or more amino groups. GO:0046203 The chemical reactions and pathways resulting in the breakdown of spermidine, N-(3-aminopropyl)-1,4-diaminobutane. GO:0016811 Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.472
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 6 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

6
  • GO:0033969 Catalysis of the reaction: 4-(L-gamma-glutamylamino)butanoate + H2O = 4-aminobutanoate + L-glutamate.
  • GO:0046872 Binding to a metal ion.
  • GO:0006598 The chemical reactions and pathways resulting in the breakdown of polyamines, any organic compound containing two or more amino groups.
  • GO:0046203 The chemical reactions and pathways resulting in the breakdown of spermidine, N-(3-aminopropyl)-1,4-diaminobutane.
  • GO:0016811 Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide.
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
2 250 FunFam G3DSA:3.40.50.880:FF:000030 Gamma-glutamyl-gamma-aminobutyrate hydrolase PuuD
4 246 SUPERFAMILY SSF52317 Class I glutamine amidotransferase-like
4 246 InterPro IPR029062 Class I glutamine amidotransferase-like
7 240 CDD cd01745 GATase1_2
15 249 ProSiteProfiles PS51273 Glutamine amidotransferase type 1 domain profile.
5 223 Pfam PF07722 Peptidase C26
5 223 InterPro IPR011697 Peptidase C26
4 242 PANTHER PTHR43235 GLUTAMINE AMIDOTRANSFERASE PB2B2.05-RELATED
4 242 InterPro IPR044668 Peptidase C26, gamma-glutamyl-gamma-aminobutyrate hydrolase PuuD-like
2 250 Gene3D G3DSA:3.40.50.880 -
2 250 InterPro IPR029062 Class I glutamine amidotransferase-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

3 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 7D4R
X-ray 1.60 Å A,B
100.0% 1-250
PDBe RCSB PDBj File
Viewing
PDB 7D53
X-ray 1.60 Å A,B,C,D
100.0% 1-250
PDBe RCSB PDBj File
Loaded
PDB 7D50
X-ray 1.77 Å A,B
100.0% 1-250
PDBe RCSB PDBj File
Loaded
AlphaFold PA0297
AlphaFold — — full sequence — Loaded
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