Protein profile

PA0330

ribose-5-phosphate isomerase A

Genome: NC_002516.2

Gene: PA0330 rpiA Structure source: Experimental + AlphaFold UniProt Q9I6G1
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Amino acids 223
Annotations 5
Features 17
PDB binders 5
Druggability 0.238

Overview

Basic information about this protein and its source genome.

Accession
PA0330
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0330 rpiA
Status
annotated
Amino acids
223
Structure source
Experimental + AlphaFold
EC
5.3.1.6
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004751 Catalysis of the reaction: aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate. GO:0006014 The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. GO:0009052 The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
36.638
Human E-value
1.5e-26
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.238
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0004751 Catalysis of the reaction: aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate.
  • GO:0006014 The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12.
  • GO:0009052 The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
129 200 Gene3D G3DSA:3.30.70.260 -
1 150 SUPERFAMILY SSF100950 NagB/RpiA/CoA transferase-like
1 150 InterPro IPR037171 NagB/RpiA transferase-like
53 217 Pfam PF06026 Ribose 5-phosphate isomerase A (phosphoriboisomerase A)
53 217 InterPro IPR004788 Ribose 5-phosphate isomerase, type A
131 202 SUPERFAMILY SSF75445 D-ribose-5-phosphate isomerase (RpiA), lid domain
129 200 FunFam G3DSA:3.30.70.260:FF:000004 Ribose-5-phosphate isomerase A
6 214 CDD cd01398 RPI_A
6 214 InterPro IPR004788 Ribose 5-phosphate isomerase, type A
3 221 Hamap MF_00170 Ribose-5-phosphate isomerase A [rpiA].
3 221 InterPro IPR020672 Ribose-5-phosphate isomerase, type A, subgroup
7 219 NCBIfam TIGR00021 ribose 5-phosphate isomerase A
7 219 InterPro IPR004788 Ribose 5-phosphate isomerase, type A
6 211 Gene3D G3DSA:3.40.50.1360 -
2 221 PANTHER PTHR11934 RIBOSE-5-PHOSPHATE ISOMERASE
2 221 InterPro IPR004788 Ribose 5-phosphate isomerase, type A
6 141 FunFam G3DSA:3.40.50.1360:FF:000001 Ribose-5-phosphate isomerase A

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 4X84
X-ray 1.25 Å A,B,C,D
100.0% 1-223
PDBe RCSB PDBj File
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AlphaFold PA0330
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.238

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 15.22 0.749
2 2.25 0.056
3 1.14 0.009

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

55 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

Show only:
Ligand Source crystal MW · LogP · TPSA Lipinski PAINS SMILES
FLC
4X84 1.25 Å Open crystal
189.1 Da LogP -5.25 TPSA 140.6 ✓ Ro5 ✓ Clean C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.