Protein profile

PA0344

hypothetical protein

Genome: NC_002516.2

Gene: PA0344 Structure source: AlphaFold UniProt Q9I6E9
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Amino acids 459
Annotations 5
Features 11
PDB binders 0
Druggability 0.825

Overview

Basic information about this protein and its source genome.

Accession
PA0344
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0344
Status
annotated
Amino acids
459
Structure source
AlphaFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005525 Binding to GTP, guanosine triphosphate. GO:0030488 The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule. GO:0002098 The process in which a uridine at position 34 of a tRNA is post-transcriptionally modified. The wobble nucleoside of the tRNA sequence (position 34) corresponds to the first position of the anticodon.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.825
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0005525 Binding to GTP, guanosine triphosphate.
  • GO:0030488 The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule.
  • GO:0002098 The process in which a uridine at position 34 of a tRNA is post-transcriptionally modified. The wobble nucleoside of the tRNA sequence (position 34) corresponds to the first position of the anticodon.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
165 450 Pfam PF11981 Domain of unknown function (DUF3482)
165 450 InterPro IPR021871 Protein of unknown function DUF3482
4 168 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
4 168 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
3 239 PANTHER PTHR42714 TRNA MODIFICATION GTPASE GTPBP3
7 186 Gene3D G3DSA:3.40.50.300 -
7 186 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
8 197 CDD cd00882 Ras_like_GTPase
418 441 MobiDBLite mobidb-lite consensus disorder prediction
8 152 Pfam PF01926 50S ribosome-binding GTPase
8 152 InterPro IPR006073 GTP binding domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0344
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.605
10 0.245