Protein profile

PA0358

hypothetical protein

Genome: NC_002516.2

Gene: PA0358 Structure source: AlphaFold UniProt Q9I6D6
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Amino acids 192
Annotations 3
Features 7
PDB binders 0
Druggability 0.815

Overview

Basic information about this protein and its source genome.

Accession
PA0358
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0358
Status
annotated
Amino acids
192
Structure source
AlphaFold
GO
GO:0003841 Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate. GO:0006654 The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. GO:0016746 Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.815
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0003841 Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate.
  • GO:0006654 The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
  • GO:0016746 Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
38 150 SMART SM00563 plsc_2
38 150 InterPro IPR002123 Phospholipid/glycerol acyltransferase
23 164 SUPERFAMILY SSF69593 Glycerol-3-phosphate (1)-acyltransferase
16 178 CDD cd07988 LPLAT_ABO13168-like
21 168 PANTHER PTHR10434 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE
31 146 Pfam PF01553 Acyltransferase
31 146 InterPro IPR002123 Phospholipid/glycerol acyltransferase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0358
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.815