Protein profile

PA0362

4Fe-4S ferredoxin

Genome: NC_002516.2

Gene: fdx1 PA0362 Structure source: Experimental + AlphaFold UniProt Q9I6D2
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Amino acids 83
Annotations 3
Features 13
PDB binders 0
Druggability 0.704

Overview

Basic information about this protein and its source genome.

Accession
PA0362
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
fdx1 PA0362
Status
annotated
Amino acids
83
Structure source
Experimental + AlphaFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.704
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MSLKITDDCINCDVCEPECPNGAISQGEEIYVIDPNLCTECVGHYDEPQCQQVCPVDCIPLDDANVESKDQLMEKYRKITGKA

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
  • GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
9 20 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature.
9 20 InterPro IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site
5 76 SUPERFAMILY SSF54862 4Fe-4S ferredoxins
1 29 ProSiteProfiles PS51379 4Fe-4S ferredoxin-type iron-sulfur binding domain profile.
1 29 InterPro IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain
5 75 PANTHER PTHR24960 PHOTOSYSTEM I IRON-SULFUR CENTER-RELATED
31 64 ProSiteProfiles PS51379 4Fe-4S ferredoxin-type iron-sulfur binding domain profile.
31 64 InterPro IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain
2 83 Gene3D G3DSA:3.30.70.20 -
5 25 Pfam PF00037 4Fe-4S binding domain
5 25 InterPro IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain
2 83 FunFam G3DSA:3.30.70.20:FF:000004 4Fe-4S ferredoxin
1 79 NCBIfam NF033683 YfhL family 4Fe-4S dicluster ferredoxin

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 2FGO
X-ray 1.32 Å A
98.8% 2-83
PDBe RCSB PDBj File
Viewing
AlphaFold PA0362
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.704

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.13 0.106
2 3.05 0.101