Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA0368
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA0368
Status: annotated
Amino acids: 332
Structure source: AlphaFold

GO

GO:0047372 Catalysis of the reaction: a monoacylglycerol + H2O = a fatty acid + glycerol + H+. GO:0034338 Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms. GO:0006629 The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

Target profile

Computed evidence for target prioritization.

Human off-target: hit
Human identity (%): 38.931
Human E-value: 3.34e-20
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.875

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3

GO:0047372 Catalysis of the reaction: a monoacylglycerol + H2O = a fatty acid + glycerol + H+.
GO:0034338 Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms.
GO:0006629 The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records

Show feature table

Start	End	DB	Term	Name
39	331	Gene3D	G3DSA:3.40.50.1820	alpha/beta hydrolase
39	331	InterPro	IPR029058	Alpha/Beta hydrolase fold
6	329	PANTHER	PTHR10794	ABHYDROLASE DOMAIN-CONTAINING PROTEIN
43	324	FunFam	G3DSA:3.40.50.1820:FF:000080	Alpha/beta hydrolase
60	308	Pfam	PF00561	alpha/beta hydrolase fold
60	308	InterPro	IPR000073	Alpha/beta hydrolase fold-1
1	332	PIRSF	PIRSF005211	Ab_hydro_YheT
1	332	InterPro	IPR012020	AB hydrolase 4 family
24	310	SUPERFAMILY	SSF53474	alpha/beta-Hydrolases
24	310	InterPro	IPR029058	Alpha/Beta hydrolase fold
233	274	ProSitePatterns	PS01133	Uncharacterized protein family UPF0017 signature.
233	274	InterPro	IPR000952	AB hydrolase 4, conserved site

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0368	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.875

PA0368