Protein profile

PA0373

signal recognition particle receptor FtsY

Genome: NC_002516.2

Gene: PA0373 ftsY Structure source: AlphaFold UniProt Q9I6C1

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Amino acids 455

Annotations 9

Features 30

PDB binders 9

Druggability 0.353

Overview

Basic information about this protein and its source genome.

Accession: PA0373
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA0373 ftsY
Status: annotated
Amino acids: 455
Structure source: AlphaFold

3.6.5.4

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005525 Binding to GTP, guanosine triphosphate. GO:0003924 Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0005047 Binding to a signal recognition particle. GO:0006605 The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.

Target profile

Computed evidence for target prioritization.

Human off-target: hit
Human identity (%): 37.5
Human E-value: 1.74e-31
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.353

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 8 GO

Enzyme Commission (EC)

3.6.5.4

Gene Ontology (GO)

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0005525 Binding to GTP, guanosine triphosphate.
GO:0003924 Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
GO:0005047 Binding to a signal recognition particle.
GO:0006605 The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.
GO:0006614 The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.
GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.

Sequence Features

Domain/signature hits from InterPro and related databases.

30 records

Show feature table

Start	End	DB	Term	Name
242	450	FunFam	G3DSA:3.40.50.300:FF:000053	Signal recognition particle receptor FtsY
346	366	Coils	Coil	Coil
250	449	Pfam	PF00448	SRP54-type protein, GTPase domain
250	449	InterPro	IPR000897	Signal recognition particle, SRP54 subunit, GTPase domain
178	449	NCBIfam	TIGR00064	signal recognition particle-docking protein FtsY
178	449	InterPro	IPR004390	Signal-recognition particle receptor FtsY
244	454	Gene3D	G3DSA:3.40.50.300	-
244	454	InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
149	239	Gene3D	G3DSA:1.20.120.140	-
149	239	InterPro	IPR042101	Signal recognition particle SRP54, N-terminal domain superfamily
248	395	SMART	SM00382	AAA_5
248	395	InterPro	IPR003593	AAA+ ATPase domain
148	228	SUPERFAMILY	SSF47364	Domain of the SRP/SRP receptor G-proteins
148	228	InterPro	IPR036225	SRP/SRP receptor, N-terminal
177	450	Hamap	MF_00920	Signal recognition particle receptor FtsY [ftsY].
177	450	InterPro	IPR004390	Signal-recognition particle receptor FtsY
250	448	CDD	cd17874	FtsY
153	234	SMART	SM00963	SRP54_N_2
153	234	InterPro	IPR013822	Signal recognition particle SRP54, helical bundle
249	450	SMART	SM00962	SRP54_3
249	450	InterPro	IPR000897	Signal recognition particle, SRP54 subunit, GTPase domain
423	436	ProSitePatterns	PS00300	SRP54-type proteins GTP-binding domain signature.
423	436	InterPro	IPR000897	Signal recognition particle, SRP54 subunit, GTPase domain
143	238	FunFam	G3DSA:1.20.120.140:FF:000002	Signal recognition particle receptor FtsY
1	147	MobiDBLite	mobidb-lite	consensus disorder prediction
49	449	PANTHER	PTHR43134	SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA
247	449	SUPERFAMILY	SSF52540	P-loop containing nucleoside triphosphate hydrolases
247	449	InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
165	230	Pfam	PF02881	SRP54-type protein, helical bundle domain
165	230	InterPro	IPR013822	Signal recognition particle SRP54, helical bundle

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0373	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
3				0.353
7				0.352
1				0.305

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

59 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

No PDB structure with a co-crystallized ligand found for this exact protein.

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Ligand	Source crystal	UniProt (homolog)	MW · LogP · TPSA	Lipinski	PAINS	SMILES
0O2	7O9H	P10121	683.1 Da LogP -2.10 TPSA 392.2	3 viol.	✓ Clean	`c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O…`
4ME	6CVD	P10121	175.2 Da LogP 1.95 TPSA 42.1	✓ Ro5	✓ Clean	`COC(=O)c1cccc2c1cc[nH]2`
ALF	4C7O	P10121	103.0 Da LogP 1.30 TPSA 0.0	✓ Ro5	✓ Clean	`F[Al-](F)(F)F`
F9Y	6CS8	P10121	142.2 Da LogP 2.04 TPSA 39.6	✓ Ro5	✓ Clean	`c1cc(cc2c1cc[nH]2)C#N`
GCP	5L3R	O80842	521.2 Da LogP -2.22 TPSA 289.9	3 viol.	✓ Clean	`c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O…`
GNP	5NIY	P10121	522.2 Da LogP -2.76 TPSA 301.9	3 viol.	✓ Clean	`c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O…`
GXY	6DLX	P10121	232.1 Da LogP 2.05 TPSA 44.5	✓ Ro5	✓ Clean	`COc1cc(c(cc1Br)OC)N`
MLI	2OG2	O80842	102.0 Da LogP -3.12 TPSA 80.3	✓ Ro5	✓ Clean	`C(C(=O)[O-])C(=O)[O-]`
NH4	6CVD	P10121	18.0 Da LogP 0.38 TPSA 36.5	✓ Ro5	✓ Clean	`[NH4+]`

Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL bioactivity data found for this exact protein.

Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL hits found through similar proteins.

Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).

Ligand	Tanimoto	MW · LogP · TPSA	Lipinski	PAINS	SMILES
ZINC9372393	1.000	232.1 Da LogP 2.05 TPSA 44.5	✓ Ro5	✓ Clean	`COc1cc(Br)c(OC)cc1N`
ZINC34541308	0.850	443.2 Da LogP -2.45 TPSA 252.6	2 viol.	✓ Clean	`Nc1nc2c(ncn2[C@@H]2O[C@H](CO[P@@](=O)(O)OP(=O)(…`
ZINC104869865	0.836	443.2 Da LogP -2.45 TPSA 252.6	2 viol.	✓ Clean	`Nc1nc2c(ncn2[C@H]2O[C@H](CO[P@@](=O)(O)OP(=O)(O…`
ZINC12504289	0.836	443.2 Da LogP -2.45 TPSA 252.6	2 viol.	✓ Clean	`Nc1nc2c(ncn2[C@@H]2O[C@H](CO[P@@](=O)(O)OP(=O)(…`
ZINC35000839	0.836	443.2 Da LogP -2.45 TPSA 252.6	2 viol.	✓ Clean	`Nc1nc2c(ncn2[C@H]2O[C@@H](CO[P@@](=O)(O)OP(=O)(…`
ZINC45284491	0.836	443.2 Da LogP -2.45 TPSA 252.6	2 viol.	✓ Clean	`Nc1nc2c(ncn2[C@H]2O[C@@H](CO[P@@](=O)(O)OP(=O)(…`
ZINC80639694	0.836	443.2 Da LogP -2.45 TPSA 252.6	2 viol.	✓ Clean	`Nc1nc2c(ncn2[C@@H]2O[C@H](CO[P@@](=O)(O)OP(=O)(…`
ZINC8215481	0.836	443.2 Da LogP -2.45 TPSA 252.6	2 viol.	✓ Clean	`Nc1nc2c(ncn2[C@@H]2O[C@H](CO[P@@](=O)(O)OP(=O)(…`
ZINC36181635	0.826	232.1 Da LogP 2.05 TPSA 44.5	✓ Ro5	✓ Clean	`COc1cc(OC)c(Br)cc1N`
ZINC39590917	0.783	217.1 Da LogP 1.62 TPSA 61.3	✓ Ro5	✓ Clean	`COc1cc(N)c(N)cc1Br`
ZINC494861	0.783	280.9 Da LogP 2.80 TPSA 35.2	✓ Ro5	✓ Clean	`COc1cc(Br)c(Br)cc1N`
ZINC12501413	0.770	363.2 Da LogP -2.57 TPSA 206.0	1 viol.	✓ Clean	`Nc1nc2c(ncn2[C@@H]2O[C@H](COP(=O)(O)O)[C@@H](O)…`
ZINC12958448	0.770	363.2 Da LogP -2.57 TPSA 206.0	1 viol.	✓ Clean	`Nc1nc2c(ncn2[C@@H]2O[C@H](COP(=O)(O)O)[C@H](O)[…`
ZINC1532555	0.770	363.2 Da LogP -2.57 TPSA 206.0	1 viol.	✓ Clean	`Nc1nc2c(ncn2[C@H]2O[C@@H](COP(=O)(O)O)[C@H](O)[…`
ZINC16546189	0.770	363.2 Da LogP -2.57 TPSA 206.0	1 viol.	✓ Clean	`Nc1nc2c(ncn2[C@@H]2O[C@H](COP(=O)(O)O)[C@H](O)[…`
ZINC2159505	0.770	363.2 Da LogP -2.57 TPSA 206.0	1 viol.	✓ Clean	`Nc1nc2c(ncn2[C@@H]2O[C@H](COP(=O)(O)O)[C@@H](O)…`
ZINC3073318	0.770	363.2 Da LogP -2.57 TPSA 206.0	1 viol.	✓ Clean	`Nc1nc2c(ncn2[C@H]2O[C@@H](COP(=O)(O)O)[C@@H](O)…`
ZINC3869963	0.770	363.2 Da LogP -2.57 TPSA 206.0	1 viol.	✓ Clean	`Nc1nc2c(ncn2[C@H]2O[C@@H](COP(=O)(O)O)[C@@H](O)…`
ZINC3869965	0.770	363.2 Da LogP -2.57 TPSA 206.0	1 viol.	✓ Clean	`Nc1nc2c(ncn2[C@@H]2O[C@@H](COP(=O)(O)O)[C@@H](O…`
ZINC9334496	0.770	363.2 Da LogP -2.57 TPSA 206.0	1 viol.	✓ Clean	`Nc1nc2c(ncn2[C@H]2O[C@@H](COP(=O)(O)O)[C@H](O)[…`
ZINC72204055	0.750	280.9 Da LogP 2.80 TPSA 35.2	✓ Ro5	✓ Clean	`COc1cc(Br)c(N)cc1Br`
ZINC8737772	0.750	280.9 Da LogP 2.80 TPSA 35.2	✓ Ro5	✓ Clean	`COc1cc(N)c(Br)cc1Br`
ZINC16678131	0.720	216.1 Da LogP 2.35 TPSA 35.2	✓ Ro5	✓ Clean	`COc1cc(N)c(C)cc1Br`
ZINC4707252	0.720	402.1 Da LogP 4.06 TPSA 70.5	✓ Ro5	✓ Clean	`COc1cc(-c2cc(OC)c(N)cc2Br)c(Br)cc1N`
ZINC57059	0.714	296.0 Da LogP 3.23 TPSA 18.5	✓ Ro5	✓ Clean	`COc1cc(Br)c(OC)cc1Br`
ZINC1685331	0.708	232.1 Da LogP 2.05 TPSA 44.5	✓ Ro5	✓ Clean	`COc1cc(N)c(Br)cc1OC`
ZINC1532902	0.700	206.2 Da LogP -0.86 TPSA 132.1	✓ Ro5	✓ Clean	`O=C(O)CC[C@@](O)(CC(=O)O)C(=O)O`
ZINC2018106	0.700	206.2 Da LogP -0.86 TPSA 132.1	✓ Ro5	✓ Clean	`O=C(O)CC[C@](O)(CC(=O)O)C(=O)O`
ZINC40571453	0.692	216.1 Da LogP 2.35 TPSA 35.2	✓ Ro5	✓ Clean	`COc1cc(Br)c(C)cc1N`
ZINC33358958	0.686	203.2 Da LogP 1.31 TPSA 59.2	✓ Ro5	✓ Clean	`COC(=O)c1cccc2c(=O)[nH]ccc12`
ZINC71774763	0.671	432.3 Da LogP -2.23 TPSA 198.3	1 viol.	✓ Clean	`Nc1nc2c(ncn2[C@@H]2O[C@H](CO[P@](=O)(O)N3CCOCC3…`
ZINC14982814	0.667	233.2 Da LogP 1.74 TPSA 68.4	✓ Ro5	✓ Clean	`COC(=O)c1cc(C(=O)OC)c2cc[nH]c2c1`
ZINC149859436	0.667	327.9 Da LogP 2.64 TPSA 35.2	✓ Ro5	✓ Clean	`COc1cc(N)c(I)cc1Br`
ZINC15444513	0.667	236.5 Da LogP 2.69 TPSA 35.2	✓ Ro5	✓ Clean	`COc1cc(Br)c(Cl)cc1N`
ZINC20283497	0.667	304.3 Da LogP 2.55 TPSA 89.0	✓ Ro5	✓ Clean	`COc1cc(-c2cc(OC)c(N)cc2OC)c(OC)cc1N`
ZINC34363585	0.667	236.5 Da LogP 2.69 TPSA 35.2	✓ Ro5	✓ Clean	`COc1cc(N)c(Cl)cc1Br`
ZINC39619094	0.667	220.0 Da LogP 2.18 TPSA 35.2	✓ Ro5	✓ Clean	`COc1cc(N)c(F)cc1Br`
ZINC77032296	0.667	220.0 Da LogP 2.18 TPSA 35.2	✓ Ro5	✓ Clean	`COc1cc(Br)c(F)cc1N`
ZINC97447173	0.667	218.0 Da LogP 1.75 TPSA 55.5	✓ Ro5	✓ Clean	`COc1cc(N)c(O)cc1Br`
ZINC97447174	0.667	218.0 Da LogP 1.75 TPSA 55.5	✓ Ro5	✓ Clean	`COc1cc(Br)c(O)cc1N`
ZINC83428754	0.654	216.1 Da LogP 2.35 TPSA 35.2	✓ Ro5	✓ Clean	`COc1cc(C)c(N)cc1Br`
ZINC163122	0.652	247.1 Da LogP 2.47 TPSA 27.7	✓ Ro5	✓ Clean	`COc1cc(OC)c(OC)cc1Br`
ZINC1721293	0.652	344.8 Da LogP 3.98 TPSA 9.2	✓ Ro5	✓ Clean	`COc1cc(Br)c(Br)cc1Br`
ZINC3593496	0.652	206.2 Da LogP -1.16 TPSA 121.1	✓ Ro5	✓ Clean	`COC(=O)C[C@@](O)(CC(=O)O)C(=O)O`
ZINC3593497	0.652	206.2 Da LogP -1.16 TPSA 121.1	✓ Ro5	✓ Clean	`COC(=O)C[C@](O)(CC(=O)O)C(=O)O`
ZINC4743771	0.652	361.3 Da LogP -2.70 TPSA 182.6	1 viol.	✓ Clean	`CS(=O)(=O)OC[C@H]1O[C@@H](n2cnc3c(=O)[nH]c(N)nc…`
ZINC4743772	0.652	361.3 Da LogP -2.70 TPSA 182.6	1 viol.	✓ Clean	`CS(=O)(=O)OC[C@@H]1O[C@@H](n2cnc3c(=O)[nH]c(N)n…`
ZINC4743774	0.652	361.3 Da LogP -2.70 TPSA 182.6	1 viol.	✓ Clean	`CS(=O)(=O)OC[C@H]1O[C@@H](n2cnc3c(=O)[nH]c(N)nc…`
ZINC4743775	0.652	361.3 Da LogP -2.70 TPSA 182.6	1 viol.	✓ Clean	`CS(=O)(=O)OC[C@@H]1O[C@@H](n2cnc3c(=O)[nH]c(N)n…`
ZINC238405705	0.649	203.2 Da LogP 1.31 TPSA 59.2	✓ Ro5	✓ Clean	`COC(=O)c1cccc2[nH]ccc(=O)c12`

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.