Protein profile

PA0380

sulfur carrier protein ThiS

Genome: NC_002516.2

Gene: PA0380 Structure source: AlphaFold UniProt Q9I6B5
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Amino acids 66
Annotations 3
Features 11
PDB binders 0

Overview

Basic information about this protein and its source genome.

Accession
PA0380
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0380
Status
annotated
Amino acids
66
Structure source
AlphaFold
GO
GO:1902503 A protein complex which is capable of adenylyltransferase activity. GO:0097163 Covalently binding to sulfur and delivering it to an acceptor molecule. GO:0052837 The chemical reactions and pathways resulting in the formation of a thiazole, a five-membered heterocyclic ring structure containing a sulfur in the 1-position and a nitrogen in the 3-position.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Unknown

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:1902503 A protein complex which is capable of adenylyltransferase activity.
  • GO:0097163 Covalently binding to sulfur and delivering it to an acceptor molecule.
  • GO:0052837 The chemical reactions and pathways resulting in the formation of a thiazole, a five-membered heterocyclic ring structure containing a sulfur in the 1-position and a nitrogen in the 3-position.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
1 66 Gene3D G3DSA:3.10.20.30 -
1 66 InterPro IPR012675 Beta-grasp domain superfamily
3 66 Pfam PF02597 ThiS family
3 66 InterPro IPR003749 Sulfur carrier ThiS/MoaD-like
3 66 CDD cd00565 Ubl_ThiS
1 66 PANTHER PTHR34472 SULFUR CARRIER PROTEIN THIS
1 66 InterPro IPR010035 ThiS, thiamine-biosynthesis
3 66 NCBIfam TIGR01683 sulfur carrier protein ThiS
3 66 InterPro IPR010035 ThiS, thiamine-biosynthesis
2 65 SUPERFAMILY SSF54285 MoaD/ThiS
2 65 InterPro IPR016155 Molybdopterin synthase/thiamin biosynthesis sulphur carrier, beta-grasp

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0380
AlphaFold — — full sequence — Viewing