Protein profile

PA0394

hypothetical protein

Genome: NC_002516.2

Gene: PA0394 Structure source: AlphaFold UniProt P24562
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Amino acids 230
Annotations 2
Features 18
PDB binders 0
Druggability 0.559

Overview

Basic information about this protein and its source genome.

Accession
PA0394
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0394
Status
annotated
Amino acids
230
Structure source
AlphaFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0030170 Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
40.299
Human E-value
1.46e-16
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.559
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0030170 Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
3 226 PANTHER PTHR10146 PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN
3 226 InterPro IPR011078 Pyridoxal phosphate homeostasis protein
76 90 ProSitePatterns PS01211 Uncharacterized protein family UPF0001 signature.
76 90 InterPro IPR011078 Pyridoxal phosphate homeostasis protein
3 222 CDD cd06824 PLPDE_III_Yggs_like
6 222 Hamap MF_02087 Pyridoxal phosphate homeostasis protein.
6 222 InterPro IPR011078 Pyridoxal phosphate homeostasis protein
1 221 SUPERFAMILY SSF51419 PLP-binding barrel
1 221 InterPro IPR029066 PLP-binding barrel
9 223 Pfam PF01168 Alanine racemase, N-terminal domain
9 223 InterPro IPR001608 Alanine racemase, N-terminal
1 223 NCBIfam TIGR00044 YggS family pyridoxal phosphate-dependent enzyme
1 223 InterPro IPR011078 Pyridoxal phosphate homeostasis protein
1 228 PIRSF PIRSF004848 YBL036c_PLPDEIII
1 228 InterPro IPR011078 Pyridoxal phosphate homeostasis protein
1 227 Gene3D G3DSA:3.20.20.10 Alanine racemase
1 227 InterPro IPR029066 PLP-binding barrel
1 222 FunFam G3DSA:3.20.20.10:FF:000004 Pyridoxal phosphate homeostasis protein

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0394
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.559
2 0.443
3 0.283