Protein profile

PA0397

cation efflux system protein

Genome: NC_002516.2

Gene: PA0397 Structure source: Experimental + AlphaFold UniProt Q9I6A3
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Amino acids 299
Annotations 8
Features 29
PDB binders 0
Druggability 0.391

Overview

Basic information about this protein and its source genome.

Accession
PA0397
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0397
Status
annotated
Amino acids
299
Structure source
Experimental + AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0046872 Binding to a metal ion. GO:0005385 Enables the transfer of zinc (Zn) ions from one side of a membrane to the other. GO:0071577 A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. GO:0008324 Enables the transfer of cation from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
43.2
Human E-value
7.32e-20
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.391
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

8 GO

Gene Ontology (GO)

8
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0046872 Binding to a metal ion.
  • GO:0005385 Enables the transfer of zinc (Zn) ions from one side of a membrane to the other.
  • GO:0071577 A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
  • GO:0008324 Enables the transfer of cation from one side of a membrane to the other.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0006812 The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom.

Sequence Features

Domain/signature hits from InterPro and related databases.

29 records
Show feature table
Start End DB Term Name
84 106 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
11 290 PANTHER PTHR11562 CATION EFFLUX PROTEIN/ ZINC TRANSPORTER
213 286 SUPERFAMILY SSF160240 Cation efflux protein cytoplasmic domain-like
213 286 InterPro IPR036837 Cation efflux protein, cytoplasmic domain superfamily
87 106 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
107 117 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
45 49 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
21 44 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
151 171 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
172 176 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
140 150 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
13 209 SUPERFAMILY SSF161111 Cation efflux protein transmembrane domain-like
13 209 InterPro IPR027469 Cation efflux transmembrane domain superfamily
194 299 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
68 86 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
50 67 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
177 193 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 20 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
118 140 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
14 289 NCBIfam TIGR01297 cation diffusion facilitator family transporter
14 289 InterPro IPR002524 Cation efflux protein
21 43 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
19 208 Pfam PF01545 Cation efflux family
19 208 InterPro IPR002524 Cation efflux protein
182 199 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
118 139 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
155 177 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
15 208 Gene3D G3DSA:1.20.1510.10 Cation efflux protein transmembrane domain
15 208 InterPro IPR027469 Cation efflux transmembrane domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 6VD8
X-ray 2.30 Å A,B
27.4% 210-291
PDBe RCSB PDBj File
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AlphaFold PA0397
AlphaFold — — full sequence — Loaded
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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.391