Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA0404
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA0404
Status: annotated
Amino acids: 144
Structure source: AlphaFold

EC

3.1.-.-

GO

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016788 Catalysis of the hydrolysis of any ester bond. GO:0004518 Catalysis of the cleavage of ester linkages within nucleic acids. GO:0000967 Any process involved in forming the mature 5' end of an rRNA molecule. GO:0006364 Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. GO:0006139 Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.516

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 6 GO

Enzyme Commission (EC)

1

3.1.-.-

Gene Ontology (GO)

6

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0016788 Catalysis of the hydrolysis of any ester bond.
GO:0004518 Catalysis of the cleavage of ester linkages within nucleic acids.
GO:0000967 Any process involved in forming the mature 5' end of an rRNA molecule.
GO:0006364 Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
GO:0006139 Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records

Show feature table

Start	End	DB	Term	Name
7	143	FunFam	G3DSA:3.30.420.140:FF:000002	Putative pre-16S rRNA nuclease
8	108	SMART	SM00732	rnase_8s
8	108	InterPro	IPR006641	YqgF/RNase H-like domain
10	127	CDD	cd16964	YqgF
10	127	InterPro	IPR005227	Putative pre-16S rRNA nuclease
9	141	PANTHER	PTHR33317	POLYNUCLEOTIDYL TRANSFERASE, RIBONUCLEASE H-LIKE SUPERFAMILY PROTEIN
9	141	InterPro	IPR005227	Putative pre-16S rRNA nuclease
10	140	Pfam	PF03652	Holliday junction resolvase
10	140	InterPro	IPR005227	Putative pre-16S rRNA nuclease
11	139	NCBIfam	TIGR00250	Holliday junction resolvase RuvX
11	139	InterPro	IPR005227	Putative pre-16S rRNA nuclease
8	143	Hamap	MF_00651	Putative pre-16S rRNA nuclease [yqgF].
8	143	InterPro	IPR005227	Putative pre-16S rRNA nuclease
9	141	SUPERFAMILY	SSF53098	Ribonuclease H-like
9	141	InterPro	IPR012337	Ribonuclease H-like superfamily
9	144	Gene3D	G3DSA:3.30.420.140	-
9	144	InterPro	IPR037027	YqgF/RNase H-like domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0404	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
4				0.516
2				0.426

PA0404