Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA0406
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: tonB3 PA0406
Status: annotated
Amino acids: 319
Structure source: AlphaFold

GO

GO:0098797 Any protein complex that is part of the plasma membrane. GO:0031992 The biological transducer activity that accepts energy and converts it to another form, often by transfer to another molecule within the cell. GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.678

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MRHRLFRPPSADFAPRQPPRSAMNAAVLKSPSAAAGVRPADRLGFTLFIAAILHVAFILGVGFSMPAPSQISKTLEITLATFKSDKAPEKADYLAQMNQQGSGTLEHKAAPKTTEVAPFQDNQVKKVAPPATPKQARSEEAPKVAVTTTRQRQQKAPSKTQAQKAEQVAKPAPHFDSTQLSAEIASLEADLAKEQQAYAKRPRIHRLSAASTMRDKGAWYKEDWRKKIERIGNLNYPDEARRQKLYGSLRLLVSINRDGTIYEVQVLESSGEPILDQAAQRIVRLAAPYAPFSGDLADIDRLEIIRTWRFERGDRLSSK

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:0098797 Any protein complex that is part of the plasma membrane.
GO:0031992 The biological transducer activity that accepts energy and converts it to another form, often by transfer to another molecule within the cell.
GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records

Show feature table

Start	End	DB	Term	Name
45	65	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
181	311	Gene3D	G3DSA:3.30.1150.10	-
177	197	Coils	Coil	Coil
233	310	Pfam	PF03544	Gram-negative bacterial TonB protein C-terminal
233	310	InterPro	IPR037682	TonB, C-terminal
180	312	FunFam	G3DSA:3.30.1150.10:FF:000012	Energy transducer TonB
129	314	SUPERFAMILY	SSF74653	TolA/TonB C-terminal domain
33	312	PANTHER	PTHR33446	PROTEIN TONB-RELATED
43	65	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
142	165	MobiDBLite	mobidb-lite	consensus disorder prediction
235	311	NCBIfam	TIGR01352	TonB family C-terminal domain
235	311	InterPro	IPR006260	TonB/TolA, C-terminal
1	44	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
66	319	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
125	168	MobiDBLite	mobidb-lite	consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0406	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.678
2				0.21

PA0406