Protein profile

PA0411

twitching motility protein PilJ

Genome: NC_002516.2

Gene: pilJ PA0411 Structure source: Experimental + AlphaFold UniProt P42257
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Amino acids 682
Annotations 5
Features 30
PDB binders 0
Druggability 0.957

Overview

Basic information about this protein and its source genome.

Accession
PA0411
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
pilJ PA0411
Status
annotated
Amino acids
682
Structure source
Experimental + AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004888 Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
OuterMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.957
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0004888 Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
  • GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
  • GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

30 records
Show feature table
Start End DB Term Name
603 623 Coils Coil Coil
333 682 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 19 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
349 675 FunFam G3DSA:1.10.287.950:FF:000001 Methyl-accepting chemotaxis sensory transducer
440 639 CDD cd11386 MCP_signal
311 332 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
20 40 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
18 40 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
403 639 ProSiteProfiles PS50111 Bacterial chemotaxis sensory transducers domain profile.
403 639 InterPro IPR004089 Methyl-accepting chemotaxis protein (MCP) signalling domain
413 674 SMART SM00283 MA_2
413 674 InterPro IPR004089 Methyl-accepting chemotaxis protein (MCP) signalling domain
350 676 Gene3D G3DSA:1.10.287.950 -
511 538 PRINTS PR00260 Bacterial chemotaxis sensory transducer signature
511 538 InterPro IPR004090 Chemotaxis methyl-accepting receptor
434 463 PRINTS PR00260 Bacterial chemotaxis sensory transducer signature
434 463 InterPro IPR004090 Chemotaxis methyl-accepting receptor
540 569 PRINTS PR00260 Bacterial chemotaxis sensory transducer signature
540 569 InterPro IPR004090 Chemotaxis methyl-accepting receptor
19 674 PANTHER PTHR32089 METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB
39 148 Pfam PF13675 Type IV pili methyl-accepting chemotaxis transducer N-term
39 148 InterPro IPR029095 NarX-like, N-terminal
374 675 SUPERFAMILY SSF58104 Methyl-accepting chemotaxis protein (MCP) signaling domain
459 642 Pfam PF00015 Methyl-accepting chemotaxis protein (MCP) signalling domain
459 642 InterPro IPR004089 Methyl-accepting chemotaxis protein (MCP) signalling domain
310 332 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
481 501 Coils Coil Coil
41 310 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
347 398 ProSiteProfiles PS50885 HAMP domain profile.
347 398 InterPro IPR003660 HAMP domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

2 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 7ZJR
X-ray 2.50 Å A
40.2% 36-309
PDBe RCSB PDBj File
Viewing
PDB 8WDF
X-ray 3.00 Å A
38.7% 43-306
PDBe RCSB PDBj File
Loaded
AlphaFold PA0411
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.596
3 0.287