Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA0412
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: pilK GUL26_18505 PA0412 CAZ10_35350 DT376_16190 PAERUG_P19_London_7_VIM_2_05_10_02100 cheR2_2
Status: annotated
Amino acids: 291
Structure source: AlphaFold

EC

2.1.1.80

GO

GO:0098561 A transmembrane protein complex that consists of multiple methyl-accepting chemoreceptor protein subunits, a histidine kinase and a connector protein and which functions in the regulation of flagellar rotary motor activity in response to an external chemical stimulus. GO:0008276 Catalysis of the transfer of a methyl group (CH3-) to a protein. GO:0008983 Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate 5-methyl ester; this reaction is the methylation of peptidyl-L-glutamate to form peptidyl-L-glutamate 5-methyl ester. GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). GO:0032259 The process in which a methyl group is covalently attached to a molecule. GO:0008757 Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.941

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 6 GO

Enzyme Commission (EC)

1

2.1.1.80

Gene Ontology (GO)

6

GO:0098561 A transmembrane protein complex that consists of multiple methyl-accepting chemoreceptor protein subunits, a histidine kinase and a connector protein and which functions in the regulation of flagellar rotary motor activity in response to an external chemical stimulus.
GO:0008276 Catalysis of the transfer of a methyl group (CH3-) to a protein.
GO:0008983 Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate 5-methyl ester; this reaction is the methylation of peptidyl-L-glutamate to form peptidyl-L-glutamate 5-methyl ester.
GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
GO:0032259 The process in which a methyl group is covalently attached to a molecule.
GO:0008757 Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.

Sequence Features

Domain/signature hits from InterPro and related databases.

28 records

Show feature table

Start	End	DB	Term	Name
8	291	ProSiteProfiles	PS50123	CheR-type methyltransferase domain profile.
8	291	InterPro	IPR000780	MCP methyltransferase, CheR-type
7	85	SUPERFAMILY	SSF47757	Chemotaxis receptor methyltransferase CheR, N-terminal domain
86	274	Pfam	PF01739	CheR methyltransferase, SAM binding domain
86	274	InterPro	IPR022642	MCP methyltransferase, CheR-type, SAM-binding domain, C-terminal
85	284	Gene3D	G3DSA:3.40.50.150	Vaccinia Virus protein VP39
85	284	InterPro	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily
10	84	Gene3D	G3DSA:1.10.155.10	-
10	84	InterPro	IPR036804	Chemotaxis receptor methyltransferase CheR, N-terminal domain superfamily
39	52	PRINTS	PR00996	Glutamate methyltransferase family signature
39	52	InterPro	IPR000780	MCP methyltransferase, CheR-type
118	138	PRINTS	PR00996	Glutamate methyltransferase family signature
118	138	InterPro	IPR000780	MCP methyltransferase, CheR-type
79	91	PRINTS	PR00996	Glutamate methyltransferase family signature
79	91	InterPro	IPR000780	MCP methyltransferase, CheR-type
223	237	PRINTS	PR00996	Glutamate methyltransferase family signature
223	237	InterPro	IPR000780	MCP methyltransferase, CheR-type
154	170	PRINTS	PR00996	Glutamate methyltransferase family signature
154	170	InterPro	IPR000780	MCP methyltransferase, CheR-type
242	265	PRINTS	PR00996	Glutamate methyltransferase family signature
242	265	InterPro	IPR000780	MCP methyltransferase, CheR-type
17	283	SMART	SM00138	methyl_trans_3
17	283	InterPro	IPR000780	MCP methyltransferase, CheR-type
11	278	PANTHER	PTHR24422	CHEMOTAXIS PROTEIN METHYLTRANSFERASE
18	70	Pfam	PF03705	CheR methyltransferase, all-alpha domain
18	70	InterPro	IPR022641	Chemotaxis receptor methyltransferase CheR, N-terminal
87	275	SUPERFAMILY	SSF53335	S-adenosyl-L-methionine-dependent methyltransferases
87	275	InterPro	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0412	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.941

PA0412