Overview
Basic information about this protein and its source genome.
- Accession
- PA0437
- Gene
- codA PA0437
- Status
- annotated
- Amino acids
- 423
- Structure source
- AlphaFold
Target profile
Computed evidence for target prioritization.
- Human off-target
- No hit
- Gut microbiome off-target
- hit
- Essential (DEG)
- N
- Localization
- Cytoplasmic
Selected Druggability evidence
Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.
Sequence
Primary amino-acid sequence viewer.
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
Gene Ontology (GO)
5- GO:0004131 Catalysis of the reaction: cytosine + H2O = uracil + NH4+.
- GO:0035888 Catalysis of the reaction: H+ + H2O + isoguanine = NH4+ + xanthine.
- GO:0046872 Binding to a metal ion.
- GO:0006209 The chemical reactions and pathways resulting in the breakdown of cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives.
- GO:0016810 Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.
Sequence Features
Domain/signature hits from InterPro and related databases.
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 17 | 406 | SUPERFAMILY | SSF51338 | Composite domain of metallo-dependent hydrolases |
| 17 | 406 | InterPro | IPR011059 | Metal-dependent hydrolase, composite domain superfamily |
| 51 | 370 | SUPERFAMILY | SSF51556 | Metallo-dependent hydrolases |
| 51 | 370 | InterPro | IPR032466 | Metal-dependent hydrolase |
| 52 | 359 | Gene3D | G3DSA:3.20.20.140 | - |
| 42 | 398 | Pfam | PF07969 | Amidohydrolase family |
| 42 | 398 | InterPro | IPR013108 | Amidohydrolase 3 |
| 5 | 405 | Gene3D | G3DSA:2.30.40.10 | Urease, subunit C, domain 1 |
| 5 | 405 | InterPro | IPR011059 | Metal-dependent hydrolase, composite domain superfamily |
| 2 | 399 | CDD | cd01293 | Bact_CD |
| 3 | 421 | PANTHER | PTHR32027 | CYTOSINE DEAMINASE |
| 52 | 360 | FunFam | G3DSA:3.20.20.140:FF:000019 | Cytosine deaminase |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
Loading 3D structure...
Structural evidence
0 + 1Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
AlphaFold
PA0437
|
AlphaFold | — | — | full sequence | — | Viewing |
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 7 | 0.369 |
Ligand evidence
Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.
Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.
No PDB structure with a co-crystallized ligand found for this exact protein.
Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.
| Ligand | Source crystal | UniProt (homolog) | MW · LogP · TPSA | Lipinski | PAINS | SMILES |
|---|---|---|---|---|---|---|
| FPY | P25524 | 132.1 Da LogP -0.57 TPSA 61.4 | ✓ Ro5 | ✓ Clean |
C1=C([C@@H](NC(=O)N1)O)F
|
|
| HPY | P25524 | 114.1 Da LogP -0.87 TPSA 61.4 | ✓ Ro5 | ✓ Clean |
C1=CNC(=O)N[C@H]1O
|
|
| IGA | P25524 | 151.1 Da LogP -0.77 TPSA 100.5 | ✓ Ro5 | ✓ Clean |
c1[nH]c2c(n1)NC(=O)N=C2N
|
|
| MLI | O52063 | 102.0 Da LogP -3.12 TPSA 80.3 | ✓ Ro5 | ✓ Clean |
C(C(=O)[O-])C(=O)[O-]
|
|
| O7U | P25524 | 147.1 Da LogP -0.08 TPSA 84.2 | ✓ Ro5 | ✓ Clean |
C1=C[P@](=O)(NC(=O)N1)N
|
|
| PXN | P25524 | 368.5 Da LogP -0.44 TPSA 117.8 | ✓ Ro5 | ✓ Clean |
C[C@H](COCC(COC[C@@H](C)O)(COC[C@@H](C)O)COC[C@…
|
Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL bioactivity data found for this exact protein.
Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL hits found through similar proteins.
Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).
| Ligand | Tanimoto | MW · LogP · TPSA | Lipinski | PAINS | SMILES |
|---|---|---|---|---|---|
| ZINC39242626 | 0.545 | 266.3 Da LogP -0.19 TPSA 77.4 | ✓ Ro5 | ✓ Clean |
C[C@H](O)COCCOCCOCCOC[C@@H](C)O
|
| ZINC39242627 | 0.545 | 266.3 Da LogP -0.19 TPSA 77.4 | ✓ Ro5 | ✓ Clean |
C[C@@H](O)COCCOCCOCCOC[C@@H](C)O
|
| ZINC39242628 | 0.545 | 266.3 Da LogP -0.19 TPSA 77.4 | ✓ Ro5 | ✓ Clean |
C[C@H](O)COCCOCCOCCOC[C@H](C)O
|
| ZINC1703616 | 0.500 | 277.0 Da LogP -0.17 TPSA 100.4 | ✓ Ro5 | ✓ Clean |
Nc1nc(=O)[nH]c2nc(I)[nH]c12
|
PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.