Protein profile

PA0451

hypothetical protein

Genome: NC_002516.2

Gene: PA0451 Structure source: AlphaFold UniProt Q9I667
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Amino acids 443
Annotations 1
Features 34
PDB binders 0
Druggability 0.845

Overview

Basic information about this protein and its source genome.

Accession
PA0451
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0451
Status
annotated
Amino acids
443
Structure source
AlphaFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.845
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

34 records
Show feature table
Start End DB Term Name
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
20 247 Gene3D G3DSA:3.90.226.10 -
268 286 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
347 368 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
316 335 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 22 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
343 365 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
287 291 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
311 333 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
353 435 Pfam PF01957 NfeD-like C-terminal, partner-binding
353 435 InterPro IPR002810 NfeD-like, C-terminal domain
282 304 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 22 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
21 248 FunFam G3DSA:3.90.226.10:FF:000089 Membrane-bound serine protease
374 441 Gene3D G3DSA:2.40.50.140 -
374 441 InterPro IPR012340 Nucleic acid-binding, OB-fold
262 267 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 22 Phobius SIGNAL_PEPTIDE Signal peptide region
27 221 CDD cd07020 Clp_protease_NfeD_1
23 238 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
310 315 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
240 262 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
336 346 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
101 123 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
369 443 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
25 194 SUPERFAMILY SSF52096 ClpP/crotonase
25 194 InterPro IPR029045 ClpP/crotonase-like domain superfamily
292 309 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
370 436 SUPERFAMILY SSF141322 NfeD domain-like
18 22 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
239 261 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
4 438 PANTHER PTHR33507 INNER MEMBRANE PROTEIN YBBJ
7 17 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0451
AlphaFold — — full sequence — Viewing
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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.845
4 0.708
3 0.489