Protein profile

PA0454

hypothetical protein

Genome: NC_002516.2

Gene: PA0454 Structure source: AlphaFold UniProt Q9I664
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Amino acids 733
Annotations 1
Features 44
PDB binders 0
Druggability 0.883

Overview

Basic information about this protein and its source genome.

Accession
PA0454
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0454
Status
annotated
Amino acids
733
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.883
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

44 records
Show feature table
Start End DB Term Name
645 666 Coils Coil Coil
444 462 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
148 170 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
116 133 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
63 85 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
20 38 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
14 715 NCBIfam TIGR01666 YccS family putative transporter
14 715 InterPro IPR010019 Integral membrane protein, YccS
415 419 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
89 111 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
490 509 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
463 467 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
308 328 Coils Coil Coil
492 509 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
116 134 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
519 538 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
21 38 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
461 483 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
413 529 Pfam PF13515 Fusaric acid resistance protein-like
39 43 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
135 148 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
44 61 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
515 537 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
68 85 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
71 354 Pfam PF12805 FUSC-like inner membrane protein yccS
71 354 InterPro IPR032692 Integral membrane protein YccS, N-terminal
438 443 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
510 514 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
486 491 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
12 717 NCBIfam TIGR01667 YccS/YhfK family putative transporter
12 717 InterPro IPR010020 Integral membrane protein, YccS/YhfK
86 90 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
420 437 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
538 733 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 20 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
468 485 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
14 678 PANTHER PTHR30509 P-HYDROXYBENZOIC ACID EFFLUX PUMP SUBUNIT-RELATED
395 414 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
395 417 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
91 109 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
62 67 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
170 394 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
149 169 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
110 115 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0454
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.883
3 0.271
35 0.238