Protein profile

PA0457

hypothetical protein

Genome: NC_002516.2

Gene: PA0457 Structure source: AlphaFold UniProt Q9I661

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Amino acids 174

Annotations 0

Features 15

PDB binders 0

Druggability 0.331

Overview

Basic information about this protein and its source genome.

Accession: PA0457
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA0457
Status: annotated
Amino acids: 174
Structure source: AlphaFold

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.331

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records

Show feature table

Start	End	DB	Term	Name
1	26	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
31	163	SUPERFAMILY	SSF50630	Acid proteases
31	163	InterPro	IPR021109	Aspartic peptidase domain superfamily
1	24	ProSiteProfiles	PS51257	Prokaryotic membrane lipoprotein lipid attachment site profile.
9	19	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
1	26	Phobius	SIGNAL_PEPTIDE	Signal peptide region
1	8	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
1	26	SignalP_GRAM_NEGATIVE	SignalP-noTM	SignalP-noTM
20	26	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
2	169	PANTHER	PTHR38037	ZN_PROTEASE DOMAIN-CONTAINING PROTEIN
27	174	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
30	166	Pfam	PF05618	Putative ATP-dependant zinc protease
30	166	InterPro	IPR008503	Putative ATP-dependent zinc protease
30	157	Gene3D	G3DSA:2.40.70.10	Acid Proteases
30	157	InterPro	IPR021109	Aspartic peptidase domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0457	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
3				0.331