Protein profile

PA0471

transmembrane sensor

Genome: NC_002516.2

Gene: PA0471 Structure source: AlphaFold UniProt Q9I647
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Amino acids 323
Annotations 2
Features 14
PDB binders 0
Druggability 0.906

Overview

Basic information about this protein and its source genome.

Accession
PA0471
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0471
Status
annotated
Amino acids
323
Structure source
AlphaFold
GO
GO:0016989 The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity. GO:0034756 Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Periplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.906
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016989 The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity.
  • GO:0034756 Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
88 106 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
88 110 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
5 323 PIRSF PIRSF018266 FecR
5 323 InterPro IPR012373 Fe(2+)-dicitrate sensor, transmembrane component
112 241 Gene3D G3DSA:2.60.120.1440 -
1 87 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
122 209 Pfam PF04773 FecR protein
122 209 InterPro IPR006860 FecR protein
1 315 PANTHER PTHR30273 PERIPLASMIC SIGNAL SENSOR AND SIGMA FACTOR ACTIVATOR FECR-RELATED
1 315 InterPro IPR012373 Fe(2+)-dicitrate sensor, transmembrane component
16 55 Pfam PF16220 Domain of unknown function (DUF4880)
16 55 InterPro IPR032623 FecR, N-terminal
107 323 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
112 241 FunFam G3DSA:2.60.120.1440:FF:000011 Amino acid ABC transporter substrate-binding protein

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0471
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.906
4 0.605
3 0.478