Protein profile

PA0473

glutathione S-transferase

Genome: NC_002516.2

Gene: PA0473 Structure source: AlphaFold UniProt Q9I645
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Amino acids 249
Annotations 4
Features 20
PDB binders 1
Druggability 0.822

Overview

Basic information about this protein and its source genome.

Accession
PA0473
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0473
Status
annotated
Amino acids
249
Structure source
AlphaFold
GO
GO:0004364 Catalysis of the reaction: RX + glutathione = an S-substituted glutathione + a halide anion + H+. GO:0016034 Catalysis of the reaction: 4-maleylacetoacetate = 4-fumarylacetoacetate. GO:0006749 The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. GO:0006559 The chemical reactions and pathways resulting in the breakdown of L-phenylalanine.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
32.051
Human E-value
2.81e-06
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.822
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0004364 Catalysis of the reaction: RX + glutathione = an S-substituted glutathione + a halide anion + H+.
  • GO:0016034 Catalysis of the reaction: 4-maleylacetoacetate = 4-fumarylacetoacetate.
  • GO:0006749 The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
  • GO:0006559 The chemical reactions and pathways resulting in the breakdown of L-phenylalanine.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
11 207 PANTHER PTHR42673 MALEYLACETOACETATE ISOMERASE
12 195 SFLD SFLDG00358 Main (cytGST)
86 218 ProSiteProfiles PS50405 Soluble glutathione S-transferase C-terminal domain profile.
86 218 InterPro IPR010987 Glutathione S-transferase, C-terminal-like
218 249 MobiDBLite mobidb-lite consensus disorder prediction
82 200 Gene3D G3DSA:1.20.1050.10 -
93 195 CDD cd00299 GST_C_family
78 205 SUPERFAMILY SSF47616 GST C-terminal domain-like
78 205 InterPro IPR036282 Glutathione S-transferase, C-terminal domain superfamily
12 195 SFLD SFLDS00019 Glutathione Transferase (cytosolic)
12 195 InterPro IPR040079 Glutathione transferase family
5 104 SUPERFAMILY SSF52833 Thioredoxin-like
5 104 InterPro IPR036249 Thioredoxin-like superfamily
5 74 CDD cd00570 GST_N_family
9 80 Pfam PF13417 Glutathione S-transferase, N-terminal domain
9 80 InterPro IPR004045 Glutathione S-transferase, N-terminal
10 205 Gene3D G3DSA:3.40.30.10 Glutaredoxin
3 81 ProSiteProfiles PS50404 Soluble glutathione S-transferase N-terminal domain profile.
3 81 InterPro IPR004045 Glutathione S-transferase, N-terminal
82 200 FunFam G3DSA:1.20.1050.10:FF:000095 Probable glutathione S-transferase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0473
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.822

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
GSH
4JBB
A6TBY7 307.3 Da LogP -2.21 TPSA 158.8 1 viol. ✓ Clean C(CC(=O)N[C@@H](CS)C(=O)NCC(=O)O)[C@@H](C(=O)O)N

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.