Protein profile

PA0483

acetyltransferase

Genome: NC_002516.2

Gene: PA0483 Structure source: AlphaFold UniProt Q9I635

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Amino acids 147

Annotations 1

Features 9

PDB binders 0

Druggability 0.934

Overview

Basic information about this protein and its source genome.

Accession: PA0483
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA0483
Status: annotated
Amino acids: 147
Structure source: AlphaFold

GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).

Target profile

Computed evidence for target prioritization.

Human off-target: hit
Human identity (%): 40.0
Human E-value: 1.37e-06
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.934

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records

Show feature table

Start	End	DB	Term	Name
3	140	Gene3D	G3DSA:3.40.630.30	-
49	117	CDD	cd04301	NAT_SF
1	147	ProSiteProfiles	PS51186	Gcn5-related N-acetyltransferase (GNAT) domain profile.
1	147	InterPro	IPR000182	GNAT domain
3	145	SUPERFAMILY	SSF55729	Acyl-CoA N-acyltransferases (Nat)
3	145	InterPro	IPR016181	Acyl-CoA N-acyltransferase
2	146	PANTHER	PTHR43877	-
18	134	Pfam	PF00583	Acetyltransferase (GNAT) family
18	134	InterPro	IPR000182	GNAT domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0483	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
4				0.934
1				0.641
3				0.435