Protein profile

PA0486

serine/threonine protein kinase

Genome: NC_002516.2

Gene: PA0486 srkA Structure source: AlphaFold UniProt Q9I632
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Amino acids 324
Annotations 7
Features 11
PDB binders 0
Druggability 0.813

Overview

Basic information about this protein and its source genome.

Accession
PA0486
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0486 srkA
Status
annotated
Amino acids
324
Structure source
AlphaFold
EC
2.7.11.1
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000287 Binding to a magnesium (Mg) ion. GO:0106310 Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. GO:0004674 Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. GO:0006468 The process of introducing a phosphate group on to a protein.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.813
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 6 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

6
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0000287 Binding to a magnesium (Mg) ion.
  • GO:0106310 Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
  • GO:0004674 Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
  • GO:0006468 The process of introducing a phosphate group on to a protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
10 105 Gene3D G3DSA:3.30.200.70 -
1 317 Hamap MF_01497 Stress response kinase A [srkA].
1 317 InterPro IPR032882 SrkA/RdoA protein kinase
31 259 Pfam PF01636 Phosphotransferase enzyme family
31 259 InterPro IPR002575 Aminoglycoside phosphotransferase
146 312 Gene3D G3DSA:1.20.1270.170 -
2 323 PANTHER PTHR39573 STRESS RESPONSE KINASE A
2 323 InterPro IPR032882 SrkA/RdoA protein kinase
57 257 Gene3D G3DSA:1.10.510.10 Transferase(Phosphotransferase) domain 1
1 322 SUPERFAMILY SSF56112 Protein kinase-like (PK-like)
1 322 InterPro IPR011009 Protein kinase-like domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0486
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.813