Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA0487
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA0487
Status: annotated
Amino acids: 252
Structure source: AlphaFold

GO

GO:0000987 Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0030151 Binding to a molybdenum ion (Mo). GO:0015689 The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.83

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5

GO:0000987 Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers.
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
GO:0030151 Binding to a molybdenum ion (Mo).
GO:0015689 The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid.
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records

Show feature table

Start	End	DB	Term	Name
186	248	Pfam	PF03459	TOBE domain
186	248	InterPro	IPR005116	Transport-associated OB, type 1
115	176	Pfam	PF03459	TOBE domain
115	176	InterPro	IPR005116	Transport-associated OB, type 1
114	180	ProSiteProfiles	PS51866	Mop domain profile.
114	180	InterPro	IPR004606	Molybdenum-pterin binding domain
16	79	Pfam	PF00126	Bacterial regulatory helix-turn-helix protein, lysR family
16	79	InterPro	IPR000847	Transcription regulator HTH, LysR
81	108	Coils	Coil	Coil
187	251	Gene3D	G3DSA:2.40.50.100	-
7	165	PANTHER	PTHR30432	TRANSCRIPTIONAL REGULATOR MODE
113	179	NCBIfam	TIGR00638	molybdenum-pterin binding domain
113	179	InterPro	IPR004606	Molybdenum-pterin binding domain
4	102	Gene3D	G3DSA:1.10.10.10	-
4	102	InterPro	IPR036388	Winged helix-like DNA-binding domain superfamily
2	252	PIRSF	PIRSF005763	Txn_reg_ModE
2	252	InterPro	IPR016462	Molybdate-dependent transcriptional regulator ModE
11	99	SUPERFAMILY	SSF46785	Winged helix DNA-binding domain
11	99	InterPro	IPR036390	Winged helix DNA-binding domain superfamily
113	181	SUPERFAMILY	SSF50331	MOP-like
113	181	InterPro	IPR008995	Molybdate/tungstate binding, C-terminal
161	248	SUPERFAMILY	SSF50331	MOP-like
161	248	InterPro	IPR008995	Molybdate/tungstate binding, C-terminal
15	103	NCBIfam	TIGR00637	ModE molybdate transport repressor domain
15	103	InterPro	IPR003725	Molybdenum-binding protein ModE, N-terminal
103	173	Gene3D	G3DSA:2.40.50.100	-

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0487	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.83

PA0487