Protein profile

PA0489

phosphoribosyl transferase

Genome: NC_002516.2

Gene: PA0489 Structure source: AlphaFold UniProt Q9I629
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Amino acids 241
Annotations 1
Features 16
PDB binders 0
Druggability 0.527

Overview

Basic information about this protein and its source genome.

Accession
PA0489
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0489
Status
annotated
Amino acids
241
Structure source
AlphaFold
GO
GO:0016740 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.527
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016740 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
47 239 SUPERFAMILY SSF53271 PRTase-like
47 239 InterPro IPR029057 Phosphoribosyltransferase-like
7 238 PANTHER PTHR47505 DNA UTILIZATION PROTEIN YHGH
1 10 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
103 241 CDD cd06223 PRTases_typeI
103 241 InterPro IPR000836 Phosphoribosyltransferase domain
22 25 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
9 65 Pfam PF18912 Double zinc ribbon domain
9 65 InterPro IPR044005 Double zinc ribbon domain
89 241 Gene3D G3DSA:3.40.50.2020 -
89 241 InterPro IPR029057 Phosphoribosyltransferase-like
11 21 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
139 238 Pfam PF00156 Phosphoribosyl transferase domain
139 238 InterPro IPR000836 Phosphoribosyltransferase domain
26 241 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 25 Phobius SIGNAL_PEPTIDE Signal peptide region

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0489
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.527
3 0.381