Protein profile

PA0492

hypothetical protein

Genome: NC_002516.2

Gene: pxpA1 PA0492 Structure source: AlphaFold UniProt Q9I626
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Amino acids 252
Annotations 4
Features 10
PDB binders 0
Druggability 0.887

Overview

Basic information about this protein and its source genome.

Accession
PA0492
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
pxpA1 PA0492
Status
annotated
Amino acids
252
Structure source
AlphaFold
EC
3.5.2.9
GO
GO:0017168 Catalysis of the reaction: 5-oxo-L-proline + ATP + 2 H2O = L-glutamate + ADP + 2 H+ + phosphate. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.887
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0017168 Catalysis of the reaction: 5-oxo-L-proline + ATP + 2 H2O = L-glutamate + ADP + 2 H+ + phosphate.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
4 241 CDD cd11664 LamB_YcsF_like_2
1 250 PANTHER PTHR30292 UNCHARACTERIZED PROTEIN YBGL-RELATED
1 250 InterPro IPR005501 LamB/YcsF/PxpA-like
4 242 Pfam PF03746 LamB/YcsF family
4 242 InterPro IPR005501 LamB/YcsF/PxpA-like
3 246 Hamap MF_00691 5-oxoprolinase subunit A [pxpA].
3 246 InterPro IPR005501 LamB/YcsF/PxpA-like
2 250 Gene3D G3DSA:3.20.20.370 Glycoside hydrolase/deacetylase
3 249 SUPERFAMILY SSF88713 Glycoside hydrolase/deacetylase
3 249 InterPro IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0492
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.631
2 0.405