Protein profile

PA0518

cytochrome C-551

Genome: NC_002516.2

Gene: nirM PA0518 Structure source: Experimental + AlphaFold UniProt P00099
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Amino acids 104
Annotations 4
Features 25
PDB binders 0
Druggability 0.917

Overview

Basic information about this protein and its source genome.

Accession
PA0518
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
nirM PA0518
Status
annotated
Amino acids
104
Structure source
Experimental + AlphaFold
GO
GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0005506 Binding to an iron (Fe) ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Periplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.917
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
  • GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways.
  • GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
  • GO:0005506 Binding to an iron (Fe) ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records
Show feature table
Start End DB Term Name
1 22 Phobius SIGNAL_PEPTIDE Signal peptide region
25 100 Pfam PF13442 Cytochrome C oxidase, cbb3-type, subunit III
25 100 InterPro IPR009056 Cytochrome c-like domain
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 22 SignalP_EUK SignalP-noTM SignalP-noTM
25 103 SUPERFAMILY SSF46626 Cytochrome c
25 103 InterPro IPR036909 Cytochrome c-like domain superfamily
1 22 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
6 17 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
28 41 PRINTS PR00606 Class ID cytochrome C signature
28 41 InterPro IPR002324 Cytochrome c, class ID
92 102 PRINTS PR00606 Class ID cytochrome C signature
92 102 InterPro IPR002324 Cytochrome c, class ID
66 79 PRINTS PR00606 Class ID cytochrome C signature
66 79 InterPro IPR002324 Cytochrome c, class ID
81 91 PRINTS PR00606 Class ID cytochrome C signature
81 91 InterPro IPR002324 Cytochrome c, class ID
43 56 PRINTS PR00606 Class ID cytochrome C signature
43 56 InterPro IPR002324 Cytochrome c, class ID
18 22 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
23 104 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
23 104 Gene3D G3DSA:1.10.760.10 -
23 104 InterPro IPR036909 Cytochrome c-like domain superfamily
20 104 ProSiteProfiles PS51007 Cytochrome c family profile.
20 104 InterPro IPR009056 Cytochrome c-like domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

6 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 5XEC
X-ray 1.10 Å A
78.8% 23-104
PDBe RCSB PDBj File
Viewing
PDB 3X39
X-ray 1.50 Å A,B
78.8% 23-104
PDBe RCSB PDBj File
Loaded
PDB 5XED
X-ray 1.55 Å A
78.8% 23-104
PDBe RCSB PDBj File
Loaded
PDB 351C
X-ray 1.60 Å A
78.8% 23-104
PDBe RCSB PDBj File
Loaded
PDB 451C
X-ray 1.60 Å A
78.8% 23-104
PDBe RCSB PDBj File
Loaded
PDB 2EXV
X-ray 1.86 Å A,C
78.8% 23-104
PDBe RCSB PDBj File
Loaded
AlphaFold PA0518
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.917

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 17.45 0.802