Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA0535
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA0535
Status: annotated
Amino acids: 184
Structure source: AlphaFold

GO

GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.949

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3

GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records

Show feature table

Start	End	DB	Term	Name
6	76	Gene3D	G3DSA:1.10.260.40	-
6	76	InterPro	IPR010982	Lambda repressor-like, DNA-binding domain superfamily
14	69	SMART	SM00530	mbf_short4
14	69	InterPro	IPR001387	Cro/C1-type helix-turn-helix domain
55	182	SUPERFAMILY	SSF51182	RmlC-like cupins
55	182	InterPro	IPR011051	RmlC-like cupin domain superfamily
15	69	ProSiteProfiles	PS50943	Cro/C1-type HTH domain profile.
15	69	InterPro	IPR001387	Cro/C1-type helix-turn-helix domain
8	73	SUPERFAMILY	SSF47413	lambda repressor-like DNA-binding domains
8	73	InterPro	IPR010982	Lambda repressor-like, DNA-binding domain superfamily
1	183	PANTHER	PTHR46797	HTH-TYPE TRANSCRIPTIONAL REGULATOR
95	182	CDD	cd02209	cupin_XRE_C
15	69	Pfam	PF01381	Helix-turn-helix
96	184	Gene3D	G3DSA:2.60.120.10	Jelly Rolls
96	184	InterPro	IPR014710	RmlC-like jelly roll fold
115	183	Pfam	PF07883	Cupin domain
115	183	InterPro	IPR013096	Cupin 2, conserved barrel
12	69	CDD	cd00093	HTH_XRE
12	69	InterPro	IPR001387	Cro/C1-type helix-turn-helix domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0535	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.949

PA0535