Protein profile

PA0537

hypothetical protein

Genome: NC_002516.2

Gene: PA0537 Structure source: AlphaFold UniProt Q9I5Z9
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Amino acids 202
Annotations 1
Features 17
PDB binders 0
Druggability 0.844

Overview

Basic information about this protein and its source genome.

Accession
PA0537
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0537
Status
annotated
Amino acids
202
Structure source
AlphaFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.844
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
1 20 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
1 7 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 26 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 27 SignalP_EUK SignalP-noTM SignalP-noTM
35 195 Pfam PF04011 LemA family
35 195 InterPro IPR007156 MamQ/LemA
1 37 Phobius SIGNAL_PEPTIDE Signal peptide region
20 195 Gene3D G3DSA:1.20.1440.20 -
20 195 InterPro IPR023353 LemA-like domain superfamily
26 182 SUPERFAMILY SSF140478 LemA-like
26 182 InterPro IPR023353 LemA-like domain superfamily
1 23 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
1 195 PANTHER PTHR34478 PROTEIN LEMA
1 195 InterPro IPR007156 MamQ/LemA
38 202 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
20 37 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
8 19 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0537
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.698
1 0.574