Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA0540
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA0540
Status: annotated
Amino acids: 128
Structure source: AlphaFold

GO

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.883

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

23 records

Show feature table

Start	End	DB	Term	Name
76	86	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1	19	Phobius	SIGNAL_PEPTIDE	Signal peptide region
128	128	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
105	109	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
87	104	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
110	127	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
57	76	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
20	55	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
86	103	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	127	PANTHER	PTHR35371	INNER MEMBRANE PROTEIN
110	127	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	19	SignalP_EUK	SignalP-noTM	SignalP-noTM
3	127	Pfam	PF01124	MAPEG family
3	127	InterPro	IPR001129	Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein
3	14	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
2	125	SUPERFAMILY	SSF161084	MAPEG domain-like
2	125	InterPro	IPR023352	Membrane associated eicosanoid/glutathione metabolism-like domain superfamily
1	127	Gene3D	G3DSA:1.20.120.550	-
1	127	InterPro	IPR023352	Membrane associated eicosanoid/glutathione metabolism-like domain superfamily
4	26	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
15	19	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
1	2	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
56	75	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0540	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.883

PA0540