Protein profile

PA0543

hypothetical protein

Genome: NC_002516.2

Gene: PA0543 Structure source: AlphaFold UniProt Q9I5Z3
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Amino acids 322
Annotations 2
Features 11
PDB binders 0
Druggability 0.955

Overview

Basic information about this protein and its source genome.

Accession
PA0543
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0543
Status
annotated
Amino acids
322
Structure source
AlphaFold
GO
GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.955
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
46 296 SUPERFAMILY SSF53474 alpha/beta-Hydrolases
46 296 InterPro IPR029058 Alpha/Beta hydrolase fold
49 292 PANTHER PTHR43037 UNNAMED PRODUCT-RELATED
5 27 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
37 286 Gene3D G3DSA:3.40.50.1820 alpha/beta hydrolase
37 286 InterPro IPR029058 Alpha/Beta hydrolase fold
7 27 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
28 322 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
55 179 Pfam PF10503 Esterase PHB depolymerase
55 179 InterPro IPR010126 Esterase, PHB depolymerase
1 6 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0543
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.719
2 0.208