Protein profile

PA0545

hypothetical protein

Genome: NC_002516.2

Gene: PA0545 Structure source: AlphaFold UniProt Q9I5Z1
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Amino acids 434
Annotations 5
Features 46
PDB binders 0
Druggability 0.738

Overview

Basic information about this protein and its source genome.

Accession
PA0545
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0545
Status
annotated
Amino acids
434
Structure source
AlphaFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0051537 Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0050660 Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0046872 Binding to a metal ion. GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
37.5
Human E-value
8.8e-07
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.738
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MKLLWGVLAAALAAWGLTLAVDPPASLDIWVVRKQAILLTGVASFALMSLIMLLAVRPVWLEKPLDGLDRMYRLHKWAGILAIVLGLLHYLLELAGPWLAGIVGKPVKGPRVETFLDVFRGSAKELGEWSAWILGGMLLVTLWQRFPYHLWRYVHKALALVYLVLAFHSVVLAPASYWSQPAGWLVAACALLGSACALLSLSGRIGRTRRHAGVVTAVERHGESLLEVTCRLQGDWSHRAGQFAFLTCDRLEGAHPFTIASADRGCGEVRFSIKALGDYTRRLQDNLEVGARVEVEGPYGCFDFRRGLAGRQVWVAAGIGVTPFIAWLESLQAAPESAPSVELHYCVRNSQEALFAGRLRELCEHLPSVTLHIRYSDEQGKPQAAQLGVLKSAEGRWPSVWFCGPQGLADSLRRDLRRQGMPLRLFHQEAFRMR

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0051537 Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
  • GO:0050660 Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
  • GO:0046872 Binding to a metal ion.
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Sequence Features

Domain/signature hits from InterPro and related databases.

46 records
Show feature table
Start End DB Term Name
16 20 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
223 432 CDD cd06198 FNR_like_3
158 178 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
77 100 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
21 35 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
36 56 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
297 306 PRINTS PR00410 Phenol hydroxylase reductase family signature
399 407 PRINTS PR00410 Phenol hydroxylase reductase family signature
238 250 PRINTS PR00410 Phenol hydroxylase reductase family signature
313 332 PRINTS PR00410 Phenol hydroxylase reductase family signature
129 151 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
218 300 Pfam PF08022 FAD-binding domain
218 300 InterPro IPR013112 FAD-binding 8
3 21 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
34 433 SFLD SFLDG01168 Ferric reductase subgroup (FRE)
309 434 Gene3D G3DSA:3.40.50.80 -
309 434 InterPro IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
211 302 SUPERFAMILY SSF63380 Riboflavin synthase domain-like
211 302 InterPro IPR017938 Riboflavin synthase-like beta-barrel
205 300 Gene3D G3DSA:2.40.30.10 Translation factors
177 433 PANTHER PTHR47354 NADH OXIDOREDUCTASE HCR
158 177 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 20 SignalP_EUK SignalP-TM SignalP-TM
202 434 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 20 Phobius SIGNAL_PEPTIDE Signal peptide region
1 2 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
184 201 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
3 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
30 377 SFLD SFLDS00052 Ferric Reductase Domain
101 128 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
129 146 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
36 56 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
77 99 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
40 165 Pfam PF01794 Ferric reductase like transmembrane component
40 165 InterPro IPR013130 Ferric reductase transmembrane component-like domain
305 431 SUPERFAMILY SSF52343 Ferredoxin reductase-like, C-terminal NADP-linked domain
305 431 InterPro IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
181 203 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
208 305 ProSiteProfiles PS51384 Ferredoxin reductase-type FAD binding domain profile.
208 305 InterPro IPR017927 FAD-binding domain, ferredoxin reductase-type
147 157 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
315 411 Pfam PF00175 Oxidoreductase NAD-binding domain
315 411 InterPro IPR001433 Oxidoreductase FAD/NAD(P)-binding
179 183 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
57 76 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
32 204 Gene3D G3DSA:1.20.120.1770 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0545
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.738