Protein profile

PA0547

transcriptional regulator

Genome: NC_002516.2

Gene: PA0547 Structure source: AlphaFold UniProt Q9I5Y9
Export view
Amino acids 333
Annotations 4
Features 26
PDB binders 2
Druggability 0.817

Overview

Basic information about this protein and its source genome.

Accession
PA0547
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0547
Status
annotated
Amino acids
333
Structure source
AlphaFold
GO
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0008757 Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.817
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule.
  • GO:0008757 Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records
Show feature table
Start End DB Term Name
10 206 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
10 206 InterPro IPR036390 Winged helix DNA-binding domain superfamily
125 329 Gene3D G3DSA:3.40.50.150 Vaccinia Virus protein VP39
125 329 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
52 67 PRINTS PR00778 Bacterial regulatory protein ArsR family signature
52 67 InterPro IPR001845 HTH ArsR-type DNA-binding domain
20 35 PRINTS PR00778 Bacterial regulatory protein ArsR family signature
20 35 InterPro IPR001845 HTH ArsR-type DNA-binding domain
67 82 PRINTS PR00778 Bacterial regulatory protein ArsR family signature
67 82 InterPro IPR001845 HTH ArsR-type DNA-binding domain
18 95 SMART SM00418 arsrmega2
18 95 InterPro IPR001845 HTH ArsR-type DNA-binding domain
21 83 CDD cd00090 HTH_ARSR
21 83 InterPro IPR011991 ArsR-like helix-turn-helix domain
4 107 Gene3D G3DSA:1.10.10.10 -
4 107 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
8 105 ProSiteProfiles PS50987 ArsR-type HTH domain profile.
8 105 InterPro IPR001845 HTH ArsR-type DNA-binding domain
17 83 NCBIfam NF033788 metalloregulator ArsR/SmtB family transcription factor
157 272 PANTHER PTHR43861 TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED
170 264 Pfam PF08241 Methyltransferase domain
170 264 InterPro IPR013216 Methyltransferase type 11
168 267 CDD cd02440 AdoMet_MTases
157 313 SUPERFAMILY SSF53335 S-adenosyl-L-methionine-dependent methyltransferases
157 313 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
19 75 Pfam PF12840 Helix-turn-helix domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0547
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.817

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

52 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
ARS
6J0E
A0A5H1ZR36 74.9 Da LogP -0.38 TPSA 0.0 ✓ Ro5 ✓ Clean [As]
BEZ
3CCF
Q3MEY9 122.1 Da LogP 1.38 TPSA 37.3 ✓ Ro5 ✓ Clean c1ccc(cc1)C(=O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.