Protein profile

PA0550

hypothetical protein

Genome: NC_002516.2

Gene: PA0550 Structure source: AlphaFold UniProt Q9I5Y6
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Amino acids 265
Annotations 2
Features 9
PDB binders 0
Druggability 0.62

Overview

Basic information about this protein and its source genome.

Accession
PA0550
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0550
Status
annotated
Amino acids
265
Structure source
AlphaFold
GO
GO:0008903 Catalysis of the reaction: 3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate. GO:0046487 The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
49.763
Human E-value
5.46e-66
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.62
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0008903 Catalysis of the reaction: 3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate.
  • GO:0046487 The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
1 258 SUPERFAMILY SSF51658 Xylose isomerase-like
1 258 InterPro IPR036237 Xylose isomerase-like superfamily
1 262 PIRSF PIRSF006241 HyI
1 262 InterPro IPR026040 Hydroxypyruvate isomerase-like
1 261 Gene3D G3DSA:3.20.20.150 -
21 257 Pfam PF01261 Xylose isomerase-like TIM barrel
21 257 InterPro IPR013022 Xylose isomerase-like, TIM barrel domain
1 259 FunFam G3DSA:3.20.20.150:FF:000007 Hydroxypyruvate isomerase
3 258 PANTHER PTHR43489 ISOMERASE

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0550
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.62