Protein profile

PA0558

hypothetical protein

Genome: NC_002516.2

Gene: PA0558 Structure source: AlphaFold UniProt Q9I5X8
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Amino acids 255
Annotations 3
Features 8
PDB binders 0
Druggability 0.918

Overview

Basic information about this protein and its source genome.

Accession
PA0558
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0558
Status
annotated
Amino acids
255
Structure source
AlphaFold
GO
GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0008757 Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. GO:0032259 The process in which a methyl group is covalently attached to a molecule.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.918
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule.
  • GO:0008757 Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.
  • GO:0032259 The process in which a methyl group is covalently attached to a molecule.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
47 135 CDD cd02440 AdoMet_MTases
13 138 PANTHER PTHR44942 METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN
15 207 SUPERFAMILY SSF53335 S-adenosyl-L-methionine-dependent methyltransferases
15 207 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
10 241 Gene3D G3DSA:3.40.50.150 Vaccinia Virus protein VP39
10 241 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
47 135 Pfam PF08241 Methyltransferase domain
47 135 InterPro IPR013216 Methyltransferase type 11

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0558
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.918