Protein profile

PA0572

hypothetical protein

Genome: NC_002516.2

Gene: PA0572 impA Structure source: Experimental + AlphaFold UniProt Q9I5W4
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Amino acids 923
Annotations 9
Features 19
PDB binders 0
Druggability 0.819

Overview

Basic information about this protein and its source genome.

Accession
PA0572
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0572 impA
Status
annotated
Amino acids
923
Structure source
Experimental + AlphaFold
EC
3.4.24.-
GO
GO:0005615 OBSOLETE. That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. GO:0046872 Binding to a metal ion. GO:0008237 Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:1903237 Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte tethering or rolling. GO:0030163 The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. GO:0015628 The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
OuterMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.819
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 8 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

8
  • GO:0005615 OBSOLETE. That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
  • GO:0046872 Binding to a metal ion.
  • GO:0008237 Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
  • GO:1903237 Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte tethering or rolling.
  • GO:0030163 The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
  • GO:0015628 The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways.
  • GO:0043952 The process in which unfolded proteins are transported across the cytoplasmic membrane in Gram-positive and Gram-negative bacteria by the Sec complex, in a process involving proteolytic cleavage of an N-terminal signal peptide.
  • GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
84 278 Pfam PF18650 Immunomodulating metalloprotease N-terminal domain
84 278 InterPro IPR040711 Immunomodulating metalloprotease N-terminal domain
562 873 Pfam PF13402 Peptidase M60, enhancin and enhancin-like
562 873 InterPro IPR031161 Peptidase family M60 domain
38 41 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
42 923 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
710 909 Gene3D G3DSA:1.10.390.30 -
710 909 InterPro IPR042279 Peptidase M60, enhancin-like domain 3
450 794 ProSiteProfiles PS51723 Peptidase family M60 domain profile.
450 794 InterPro IPR031161 Peptidase family M60 domain
1 25 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
26 37 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 41 Phobius SIGNAL_PEPTIDE Signal peptide region
305 414 Pfam PF18642 Immunomodulating metalloprotease helical domain
305 414 InterPro IPR041549 Immunomodulating metalloprotease helical domain
450 795 SMART SM01276 M60_like_2
450 795 InterPro IPR031161 Peptidase family M60 domain
1 41 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
51 920 NCBIfam NF038322 ImpA family metalloprotease

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

4 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 5KDW
X-ray 1.85 Å A,B
95.6% 42-923
PDBe RCSB PDBj File
Viewing
PDB 5KDV
X-ray 1.93 Å A
95.6% 42-923
PDBe RCSB PDBj File
Loaded
PDB 5KDX
X-ray 2.40 Å A,B
95.6% 42-923
PDBe RCSB PDBj File
Loaded
PDB 7JTV
X-ray 2.45 Å A,B
95.6% 42-923
PDBe RCSB PDBj File
Loaded
AlphaFold PA0572
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.819
9 0.495
2 0.466

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 11.15 0.598
2 10.49 0.564
3 7.99 0.425
4 6.87 0.353
5 5.31 0.25