Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA0579
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA0579 rpsU
Status: annotated
Amino acids: 71
Structure source: AlphaFold

GO

GO:1990904 A macromolecular complex that contains both RNA and protein molecules. GO:0005840 An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:1990904 A macromolecular complex that contains both RNA and protein molecules.
GO:0005840 An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome.
GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

Sequence Features

Domain/signature hits from InterPro and related databases.

23 records

Show feature table

Start	End	DB	Term	Name
4	62	PANTHER	PTHR21109	MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S21
4	62	InterPro	IPR001911	Ribosomal protein S21
1	57	Hamap	MF_00358	30S ribosomal protein S21 [rpsU].
1	57	InterPro	IPR001911	Ribosomal protein S21
5	13	PRINTS	PR00976	Ribosomal protein S21 family signature
5	13	InterPro	IPR001911	Ribosomal protein S21
13	22	PRINTS	PR00976	Ribosomal protein S21 family signature
13	22	InterPro	IPR001911	Ribosomal protein S21
37	47	PRINTS	PR00976	Ribosomal protein S21 family signature
37	47	InterPro	IPR001911	Ribosomal protein S21
25	35	PRINTS	PR00976	Ribosomal protein S21 family signature
25	35	InterPro	IPR001911	Ribosomal protein S21
4	56	Pfam	PF01165	Ribosomal protein S21
4	56	InterPro	IPR001911	Ribosomal protein S21
13	25	ProSitePatterns	PS01181	Ribosomal protein S21 signature.
13	25	InterPro	IPR018278	Ribosomal protein S21, conserved site
43	63	Coils	Coil	Coil
49	63	MobiDBLite	mobidb-lite	consensus disorder prediction
16	54	Gene3D	G3DSA:1.20.5.1150	Ribosomal protein S8
16	54	InterPro	IPR038380	Ribosomal protein S21 superfamily
2	59	NCBIfam	TIGR00030	30S ribosomal protein S21
2	59	InterPro	IPR001911	Ribosomal protein S21
48	71	MobiDBLite	mobidb-lite	consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

No pockets are loaded yet for the displayed AlphaFold model PA0579 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0579	AlphaFold	—	—	full sequence	—	Viewing