Protein profile

PA0588

hypothetical protein

Genome: NC_002516.2

Gene: PA0588 Structure source: AlphaFold UniProt Q9I5U9
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Amino acids 640
Annotations 1
Features 13
PDB binders 0
Druggability 0.725

Overview

Basic information about this protein and its source genome.

Accession
PA0588
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0588
Status
annotated
Amino acids
640
Structure source
AlphaFold
GO
GO:0004672 Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.725
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MSIFSHFQERFEATRQEEYSLQEYLDLCKQDKTAYASAAERLLMAIGEPELLDTSVDSRLSRIFSNKVIRRYPAFADFHGMEECIDQIVAFFRHAAQGLEEKKQILYLLGPVGGGKSSLAEKLKQLMEKVPFYAIKGSPVFESPLGLFNPDEDGAILEEDYGIPRRYLRSIMSPWATKRLNEFGGDISQFRVVKLYPSILNQIAIAKTEPGDENNQDISALVGKVDIRKLEEYPQNDADAYSYSGALCRANQGLMEFVEMFKAPIKVLHPLLTATQEGNYNSTEGLGALPYSGIILAHSNESEWHSFRNNKNNEAFIDRIYIVKVPYCLRVADEIKIYDKLLVNSSLAHAHCAPDTLKMLSQFSVLSRLKEPENSNIYSKMRVYDGENLKDTDPKAKSIQEYRDSAGVDEGMAGLSTRFAFKILSKVFNFDPHEVAANPVHLLYVLEQQIEQEQFQPETRERYLRFIKEYLAPRYVEFIGKEIQTAYLESYSEYGQNIFDRYVLYADFWIQDQEYRDPETGEILNRAALNEELEKIEKPAGISNPKDFRNEIVNFVLRARAGNNGKNPSWLSYEKLRVVIEKKMFSNTEDLLPVISFNAKASKEDQQKHNDFVKRMVERGYTEKQVRLLSEWYLRVRKSQ

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0004672 Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 640 PIRSF PIRSF000549 Ser_prot_kin
1 640 InterPro IPR016230 Serine-protein kinase, PrkA
75 343 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
75 343 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
20 376 Pfam PF08298 PrkA AAA domain
20 376 InterPro IPR013153 PrkA AAA domain
19 376 SMART SM00763 aaa_prka2seq5
19 376 InterPro IPR013153 PrkA AAA domain
65 323 Gene3D G3DSA:3.40.50.300 -
65 323 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
1 639 PANTHER PTHR30267 PROTEIN KINASE PRKA
378 632 Pfam PF06798 PrkA serine protein kinase C-terminal domain
378 632 InterPro IPR010650 PrkA C-terminal domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0588
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.725
4 0.259
1 0.243