Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA0589
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA0589 glpE
Status: annotated
Amino acids: 110
Structure source: AlphaFold

EC

2.8.1.1

GO

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004792 Catalysis of the reaction: thiosulfate + hydrogen cyanide = thiocyanate + sulfite + 2 H+. GO:0103041 Catalysis of the reaction: thiosulfate + [thioredoxin]-dithiol = sulfite + 2 H+ + [thioredoxin]-disulfide + hydrogen sulfide. GO:0006791 A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary sulfur sources and then activates genes to scavenge the last traces of the primary sulfur source and to transport and metabolize alternate sulfur sources. The utilization process begins when the cell or organism detects sulfur levels, includes the activation of genes whose products detect, transport or metabolize sulfur-containing compounds, and ends when the sulfur is incorporated into the cell or organism's metabolism.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.503

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

2.8.1.1

Gene Ontology (GO)

4

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0004792 Catalysis of the reaction: thiosulfate + hydrogen cyanide = thiocyanate + sulfite + 2 H+.
GO:0103041 Catalysis of the reaction: thiosulfate + [thioredoxin]-dithiol = sulfite + 2 H+ + [thioredoxin]-disulfide + hydrogen sulfide.
GO:0006791 A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary sulfur sources and then activates genes to scavenge the last traces of the primary sulfur source and to transport and metabolize alternate sulfur sources. The utilization process begins when the cell or organism detects sulfur levels, includes the activation of genes whose products detect, transport or metabolize sulfur-containing compounds, and ends when the sulfur is incorporated into the cell or organism's metabolism.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records

Show feature table

Start	End	DB	Term	Name
10	97	Pfam	PF00581	Rhodanese-like domain
10	97	InterPro	IPR001763	Rhodanese-like domain
17	105	ProSiteProfiles	PS50206	Rhodanese domain profile.
17	105	InterPro	IPR001763	Rhodanese-like domain
3	98	PANTHER	PTHR43031	FAD-DEPENDENT OXIDOREDUCTASE
8	102	SMART	SM00450	rhod_4
8	102	InterPro	IPR001763	Rhodanese-like domain
7	97	CDD	cd01444	GlpE_ST
7	97	InterPro	IPR023695	Thiosulfate sulfurtransferase, bacterial
3	105	Hamap	MF_01009	Thiosulfate sulfurtransferase GlpE [glpE].
3	105	InterPro	IPR023695	Thiosulfate sulfurtransferase, bacterial
2	107	Gene3D	G3DSA:3.40.250.10	-
2	107	InterPro	IPR036873	Rhodanese-like domain superfamily
3	101	SUPERFAMILY	SSF52821	Rhodanese/Cell cycle control phosphatase
3	101	InterPro	IPR036873	Rhodanese-like domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0589	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.503

PA0589