Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA0611
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: prtR PA0611
Status: annotated
Amino acids: 256
Structure source: AlphaFold

GO

GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0030152 The chemical reactions and pathways resulting in the formation of a bacteriocin, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary. GO:1900377 Any process that stops, prevents or reduces the frequency, rate or extent of secondary metabolite biosynthetic process. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.706

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MDKSTQIPPDSFAARLKQAMAMRNLKQETLAEAAGVSQNTIHKLTSGKAQSTRKLIEIAAALGVSPVWLQTGEGAPAARSAVSVADGSPLVLEPLHPWDSDTPLDEDEVELPLYKEVEMSAGAGRTAVREIEGRKLRFSYATLRASGVDPSAAICAQLTGNSMEPLIMDGSTIGVDTATTHITDGEIYALEHDGMLRVKFVYRLPGGGIRLRSFNREEYPDEEYSPEDMRSRQISMIGWVFWWSTVRHRRGPSLVR

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0030152 The chemical reactions and pathways resulting in the formation of a bacteriocin, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary.
GO:1900377 Any process that stops, prevents or reduces the frequency, rate or extent of secondary metabolite biosynthetic process.
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records

Show feature table

Start	End	DB	Term	Name
112	241	Pfam	PF00717	Peptidase S24-like
112	241	InterPro	IPR015927	Peptidase S24/S26A/S26B/S26C
111	246	Gene3D	G3DSA:2.10.109.10	Umud Fragment, subunit A
154	230	CDD	cd06529	S24_LexA-like
154	230	InterPro	IPR039418	LexA-like
16	69	ProSiteProfiles	PS50943	Cro/C1-type HTH domain profile.
16	69	InterPro	IPR001387	Cro/C1-type helix-turn-helix domain
10	77	Gene3D	G3DSA:1.10.260.40	-
10	77	InterPro	IPR010982	Lambda repressor-like, DNA-binding domain superfamily
15	69	SMART	SM00530	mbf_short4
15	69	InterPro	IPR001387	Cro/C1-type helix-turn-helix domain
10	74	SUPERFAMILY	SSF47413	lambda repressor-like DNA-binding domains
10	74	InterPro	IPR010982	Lambda repressor-like, DNA-binding domain superfamily
13	69	CDD	cd00093	HTH_XRE
13	69	InterPro	IPR001387	Cro/C1-type helix-turn-helix domain
109	243	SUPERFAMILY	SSF51306	LexA/Signal peptidase
109	243	InterPro	IPR036286	LexA/Signal peptidase-like superfamily
9	247	PANTHER	PTHR40661	-
16	69	Pfam	PF01381	Helix-turn-helix

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0611	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.706
4				0.202

PA0611