Amino acids
256
Annotations
7
Features
17
PDB binders
0
Druggability
0.704
Overview
Basic information about this protein and its source genome.
- Accession
- PA0639
- Gene
- PA0639
- Status
- annotated
- Amino acids
- 256
- Structure source
- AlphaFold
GO
GO:0008234 Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
GO:0008235 Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
GO:0008270 Binding to a zinc ion (Zn).
GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
GO:0008233 Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
GO:0008237 Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
Target profile
Computed evidence for target prioritization.
- Human off-target
- No hit
- Gut microbiome off-target
- hit
- Essential (DEG)
- N
- Localization
- Cytoplasmic
Selected Druggability evidence
Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.
FPocket
0.704
Sequence
Primary amino-acid sequence viewer.
MELSRSLQRAIAAHAAREHPRECCGLIVRGVRQRRYVACRNAAGSPSEHFVIDHQDWCAAEDQGEVLAIVHSHPDVPATPSMADRVSCELHGLPWVILSWPEGDVAHLAPEGYRAPLLGREFAHGVLDCWSLCRDWYRREAGLELPDYPRRDGWWETGESLYEQHYAAAGFRPVPLAGIRRGDMLVMQVGRALHPNHAGIYLGNDWRLDSEPVQALGGDGPFLLHHLYGRLSTRDVFGGPWIERTRLVLRHTRMPQ
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
7 GO
Gene Ontology (GO)
7- GO:0008234 Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
- GO:0008235 Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
- GO:0008270 Binding to a zinc ion (Zn).
- GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
- GO:0008233 Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
- GO:0008237 Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
- GO:0005515 Binding to a protein.
Sequence Features
Domain/signature hits from InterPro and related databases.
17 records
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 113 | 253 | SUPERFAMILY | SSF54001 | Cysteine proteinases |
| 113 | 253 | InterPro | IPR038765 | Papain-like cysteine peptidase superfamily |
| 1 | 127 | SMART | SM00232 | pad1_6 |
| 1 | 127 | InterPro | IPR000555 | JAB1/MPN/MOV34 metalloenzyme domain |
| 114 | 253 | FunFam | G3DSA:3.90.1720.10:FF:000022 | Phage tail fiber protein |
| 119 | 250 | Pfam | PF00877 | NlpC/P60 family |
| 119 | 250 | InterPro | IPR000064 | Endopeptidase, NLPC/P60 domain |
| 5 | 101 | Pfam | PF14464 | Prokaryotic homologs of the JAB domain |
| 5 | 101 | InterPro | IPR028090 | JAB domain, prokaryotic |
| 114 | 249 | Gene3D | G3DSA:3.90.1720.10 | endopeptidase domain like (from Nostoc punctiforme) |
| 98 | 252 | ProSiteProfiles | PS51935 | NlpC/P60 domain profile. |
| 98 | 252 | InterPro | IPR000064 | Endopeptidase, NLPC/P60 domain |
| 7 | 114 | FunFam | G3DSA:3.40.140.10:FF:000058 | Phage tail protein |
| 1 | 139 | SUPERFAMILY | SSF102712 | JAB1/MPN domain |
| 1 | 113 | Gene3D | G3DSA:3.40.140.10 | Cytidine Deaminase, domain 2 |
| 1 | 172 | PANTHER | PTHR34858 | CYSO-CYSTEINE PEPTIDASE |
| 6 | 113 | CDD | cd08073 | MPN_NLPC_P60 |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
Loading 3D structure...
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Structural evidence
0 + 1Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
AlphaFold
PA0639
|
AlphaFold | — | — | full sequence | — | Viewing |
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 1 | 0.704 |