Protein profile

PA0654

S-adenosylmethionine decarboxylase

Genome: NC_002516.2

Gene: speD PA0654 Structure source: AlphaFold UniProt Q9I5R7
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Amino acids 264
Annotations 4
Features 13
PDB binders 0
Druggability 0.26

Overview

Basic information about this protein and its source genome.

Accession
PA0654
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
speD PA0654
Status
annotated
Amino acids
264
Structure source
AlphaFold
EC
4.1.1.50
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004014 Catalysis of the reaction: S-adenosyl-L-methionine + H+ = S-adenosylmethioninamine + CO2. GO:0008295 The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.26
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0004014 Catalysis of the reaction: S-adenosyl-L-methionine + H+ = S-adenosylmethioninamine + CO2.
  • GO:0008295 The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 264 PIRSF PIRSF001356 SAM_decarboxylas
1 264 InterPro IPR009165 S-adenosylmethionine decarboxylase, bacterial
4 262 NCBIfam TIGR03331 adenosylmethionine decarboxylase
4 262 InterPro IPR009165 S-adenosylmethionine decarboxylase, bacterial
1 264 Hamap MF_00465 S-adenosylmethionine decarboxylase proenzyme [speD].
44 174 SUPERFAMILY SSF56276 S-adenosylmethionine decarboxylase
44 174 InterPro IPR016067 S-adenosylmethionine decarboxylase, core
33 186 FunFam G3DSA:3.60.90.10:FF:000001 S-adenosylmethionine decarboxylase proenzyme
39 170 Pfam PF02675 S-adenosylmethionine decarboxylase
39 170 InterPro IPR003826 S-adenosylmethionine decarboxylase family, prokaryotic
1 195 PANTHER PTHR33866 S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME
1 195 InterPro IPR003826 S-adenosylmethionine decarboxylase family, prokaryotic
33 185 Gene3D G3DSA:3.60.90.10 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0654
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.26
3 0.25