Protein profile

PA0655

2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase

Genome: NC_002516.2

Gene: PA0655 coq7 Structure source: AlphaFold UniProt Q9I5R6
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Amino acids 215
Annotations 7
Features 14
PDB binders 0
Druggability 0.846

Overview

Basic information about this protein and its source genome.

Accession
PA0655
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0655 coq7
Status
annotated
Amino acids
215
Structure source
AlphaFold
EC
1.14.99.60
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008682 Catalysis of the reaction: a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + donor-H2 + O2 = acceptor + a 3-demethylubiquinol + H2O. GO:0046872 Binding to a metal ion. GO:0004497 Catalysis of the incorporation of one atom of molecular oxygen (O2) into the substrate and the reduction of the other atom of O2 to water. GO:0006744 The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
29.114
Human E-value
2.34e-06
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.846
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 6 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

6
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0008682 Catalysis of the reaction: a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + donor-H2 + O2 = acceptor + a 3-demethylubiquinol + H2O.
  • GO:0046872 Binding to a metal ion.
  • GO:0004497 Catalysis of the incorporation of one atom of molecular oxygen (O2) into the substrate and the reduction of the other atom of O2 to water.
  • GO:0006744 The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
53 214 CDD cd01042 DMQH
53 214 InterPro IPR011566 Ubiquinone biosynthesis protein Coq7
11 211 PANTHER PTHR11237 COENZYME Q10 BIOSYNTHESIS PROTEIN 7
11 211 InterPro IPR011566 Ubiquinone biosynthesis protein Coq7
14 215 Hamap MF_01658 3-demethoxyubiquinol 3-hydroxylase [coq7].
14 215 InterPro IPR011566 Ubiquinone biosynthesis protein Coq7
46 188 FunFam G3DSA:1.20.1260.10:FF:000013 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase
51 183 SUPERFAMILY SSF47240 Ferritin-like
51 183 InterPro IPR009078 Ferritin-like superfamily
52 209 Pfam PF03232 Ubiquinone biosynthesis protein COQ7
11 215 NCBIfam NF033656 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone monooxygenase
11 215 InterPro IPR047809 Ubiquinone biosynthesis protein Coq7, proteobacteria
46 188 Gene3D G3DSA:1.20.1260.10 -
46 188 InterPro IPR012347 Ferritin-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0655
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.846

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

47 records

Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

Show only:
Ligand UniProt (homolog) pchembl MW · LogP · TPSA Lipinski PAINS SMILES
CQL Q99807 — 305.5 Da LogP 3.20 TPSA 33.1 ✓ Ro5 ✓ Clean c1cc2c(cc(c(c2nc1)O)I)Cl

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.