Protein profile

PA0667

hypothetical protein

Genome: NC_002516.2

Gene: PA0667 Structure source: AlphaFold UniProt Q9I5Q4
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Amino acids 447
Annotations 5
Features 19
PDB binders 3
Druggability 0.32

Overview

Basic information about this protein and its source genome.

Accession
PA0667
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0667
Status
annotated
Amino acids
447
Structure source
AlphaFold
GO
GO:0030313 An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present. GO:0046872 Binding to a metal ion. GO:0004222 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0042834 Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.32
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0030313 An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present.
  • GO:0046872 Binding to a metal ion.
  • GO:0004222 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
  • GO:0042834 Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls.
  • GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
71 163 Gene3D G3DSA:3.10.450.350 -
156 404 SUPERFAMILY SSF51261 Duplicated hybrid motif
156 404 InterPro IPR011055 Duplicated hybrid motif
81 160 Pfam PF04225 Opacity-associated protein A LysM-like domain
81 160 InterPro IPR007340 Opacity-associated protein A
278 410 Gene3D G3DSA:2.70.70.10 Glucose Permease (Domain IIA)
278 410 InterPro IPR011055 Duplicated hybrid motif
32 56 MobiDBLite mobidb-lite consensus disorder prediction
83 131 ProSiteProfiles PS51782 LysM domain profile.
83 131 InterPro IPR018392 LysM domain
182 432 Gene3D G3DSA:3.10.450.350 -
78 408 PANTHER PTHR21666 PEPTIDASE-RELATED
20 77 MobiDBLite mobidb-lite consensus disorder prediction
307 403 Pfam PF01551 Peptidase family M23
307 403 InterPro IPR016047 Peptidase M23
308 393 CDD cd12797 M23_peptidase
280 409 FunFam G3DSA:2.70.70.10:FF:000002 Murein DD-endopeptidase MepM
174 294 Pfam PF19425 Csd3 second domain
174 294 InterPro IPR045834 Csd3-like, second N-terminal domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0667
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.32
2 0.312

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

22 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
4SQ
4ZYB
O33599 281.2 Da LogP -2.12 TPSA 158.8 ✓ Ro5 ✓ Clean C(CP(=O)(CNC(=O)CN)O)C(=O)NCC(=O)O
CAC
2B0P
O33599 137.0 Da LogP -0.52 TPSA 40.1 ✓ Ro5 ✓ Clean C[As](=O)(C)[O-]
TLA
2B13
O33599 150.1 Da LogP -2.12 TPSA 115.1 ✓ Ro5 ✓ Clean [C@@H]([C@H](C(=O)O)O)(C(=O)O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.