Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA0678
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA0678
Status: annotated
Amino acids: 149
Structure source: AlphaFold

GO

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015627 A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0015628 The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.805

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0015627 A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex.
GO:0015628 The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways.

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records

Show feature table

Start	End	DB	Term	Name
39	146	Gene3D	G3DSA:3.55.40.10	minor pseudopilin epsh domain
1	26	SignalP_EUK	SignalP-TM	SignalP-TM
44	137	Pfam	PF12019	Type II transport protein GspH
44	137	InterPro	IPR022346	General secretion pathway, GspH
6	148	NCBIfam	TIGR01708	type II secretion system minor pseudopilin GspH
6	148	InterPro	IPR002416	Type II secretion system protein GspH
7	29	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
7	27	ProSitePatterns	PS00409	Prokaryotic N-terminal methylation site.
7	27	InterPro	IPR012902	Prokaryotic N-terminal methylation site
6	28	NCBIfam	TIGR02532	prepilin-type N-terminal cleavage/methylation domain
6	28	InterPro	IPR012902	Prokaryotic N-terminal methylation site
1	11	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
12	32	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
19	33	PRINTS	PR00885	Bacterial general secretion pathway protein H signature
19	33	InterPro	IPR002416	Type II secretion system protein GspH
4	18	PRINTS	PR00885	Bacterial general secretion pathway protein H signature
4	18	InterPro	IPR002416	Type II secretion system protein GspH
124	139	PRINTS	PR00885	Bacterial general secretion pathway protein H signature
124	139	InterPro	IPR002416	Type II secretion system protein GspH
3	28	Pfam	PF07963	Prokaryotic N-terminal methylation motif
3	28	InterPro	IPR012902	Prokaryotic N-terminal methylation site
33	149	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
9	81	SUPERFAMILY	SSF54523	Pili subunits
9	81	InterPro	IPR045584	Pilin-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0678	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.805

PA0678