Protein profile

PA0682

HxcX atypical pseudopilin

Genome: NC_002516.2

Gene: PA0682 Structure source: AlphaFold UniProt Q9I5P3
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Amino acids 321
Annotations 3
Features 21
PDB binders 0
Druggability 0.415

Overview

Basic information about this protein and its source genome.

Accession
PA0682
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0682
Status
annotated
Amino acids
321
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0009306 The controlled release of proteins from a cell. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.415
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0009306 The controlled release of proteins from a cell.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
218 272 SUPERFAMILY SSF47781 RuvA domain 2-like
218 272 InterPro IPR010994 RuvA domain 2-like
22 25 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
6 314 NCBIfam NF037980 type II secretion system minor pseudopilin GspK
6 314 InterPro IPR005628 General secretion pathway protein K
10 21 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
26 321 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
27 130 Gene3D G3DSA:3.30.1300.30 -
31 313 Pfam PF03934 Type II secretion system (T2SS), protein K
31 313 InterPro IPR005628 General secretion pathway protein K
104 218 SUPERFAMILY SSF158544 GspK insert domain-like
104 218 InterPro IPR038072 GspK, central domain superfamily
43 320 SUPERFAMILY SSF54523 Pili subunits
43 320 InterPro IPR045584 Pilin-like
1 9 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
4 139 PANTHER PTHR38831 TYPE II SECRETION SYSTEM PROTEIN K
4 139 InterPro IPR005628 General secretion pathway protein K
1 321 PIRSF PIRSF002786 XcpX
1 321 InterPro IPR005628 General secretion pathway protein K
1 25 Phobius SIGNAL_PEPTIDE Signal peptide region

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0682
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.415
3 0.284
2 0.272